Actively Recruiting
Plaque Characteristics Predict Recurrent Stroke in MCA Stroke Patients
Led by University Medical Center Ho Chi Minh City (UMC) · Updated on 2024-05-08
125
Participants Needed
1
Research Sites
113 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The epidemiology of TOAST classification in Asian patients seems to differ due to the higher rates of large-artery atherosclerosis. The complex pathology of atherosclerosis could lead to recurrent stroke, including shear stress on the endothelium, disturbance of the flow, occlusion at the origin of the perforating artery, and other complications (plaque inflammation, plaque hemorrhage, plaque rupture) that could lead to stroke and recurrent stroke. Therefore, The exact determination of the etiology of stroke due to atherosclerosis is the most critical factor for treatment and prognostic. On the other hand, HR-MRI could be a useful imaging modality to evaluate the characteristics of plaque in stroke patients due to atherosclerosis stenosis, which will help us find out the etiology of stroke. Previous studies have demonstrated its prognosis value in predicting recurrent stroke in the same vascular territory. The investigators hypothesize that with an appropriate evaluation, HR-MRI could help to predict recurrent stroke in the same vascular territory in patients with high-risk plaque characteristics on HR-MRI. These findings could contribute to individual treatment according to etiology. The investigators intend to conduct a study to determine the correlation between plaque characteristics and recurrent stroke in the same vascular territory in ischemic stroke patients due to middle cerebral artery stenosis.
CONDITIONS
Official Title
Plaque Characteristics Predict Recurrent Stroke in MCA Stroke Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who had a first-time ischemic stroke due to middle cerebral artery atherosclerosis stenosis more than 50% and were admitted within 7 days after onset
- Patients aged more than 45 years
- Patients who had a high-resolution MRI and completed full stroke workup including carotid duplex scanning, fasting lipid profile, 24-hour Holter ECG, and cardiac ultrasound
You will not qualify if you...
- Patients with carotid artery stenosis more than 50% on the same side as the ischemic stroke
- Patients with ischemic stroke in brain areas other than the middle cerebral artery territory
- Patients with signs of other causes for stenosis such as moyamoya, dissection, or inflammation on MRI or HR-MRI
- Patients with evidence of cardioembolism including atrial fibrillation, reduced ejection fraction below 50%, recent heart attack within 3 weeks, rheumatic valvular heart disease, dilated cardiomyopathy, sick sinus syndrome, or infective endocarditis
- Patients with signs of autoimmune disease or increased blood clotting
- Patients with severe other diseases that could affect 6-month follow-up
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Medical Center Ho Chi Minh City
Ho Chi Minh City, Vietnam, 70000
Actively Recruiting
Research Team
K
Khoa Dao, MD
CONTACT
K
Khang Nguyen, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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