Actively Recruiting
Plasma Biomarkers and Platelet Morphology of Extracorporeal CardioPulmonary Resuscitation
Led by Central China Fuwai Hospital of Zhengzhou University · Updated on 2026-03-23
130
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
Sponsors
C
Central China Fuwai Hospital of Zhengzhou University
Lead Sponsor
U
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Collaborating Sponsor
AI-Summary
What this Trial Is About
Extracorporeal cardiopulmonary resuscitation (ECPR) constitutes a pivotal emergency intervention for cardiac arrest (CA) patients. However, current eligibility criteria and prognostic assessment metrics remain substantially limited, relying predominantly on clinical symptoms and physical signs while lacking objective biomarker data. Integrating reproducible, highly sensitive, and specific proteinaceous and metabolic indicators with ultrastructural platelet alterations may hold significant implications for both ECPR administration and prognostication in CA. Therefore, the purpose of this study is to identify the plasma proteomic and metabolomic characteristics of patients with refractory cardiac arrest before and after ECPR treatment, as well as the characteristics of platelet morphological and structural changes, to search for potential specific markers that can predict CA patients who may benefit from ECPR so as to optimize treatment selection.
CONDITIONS
Official Title
Plasma Biomarkers and Platelet Morphology of Extracorporeal CardioPulmonary Resuscitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years old (may be extended if organ function and neurological prognosis are good)
- Cardiac arrest was witnessed and CPR started by bystanders within 5 minutes
- Cardiac arrest caused by reversible conditions such as cardiogenic issues, pulmonary embolism, severe hypothermia, drug poisoning, trauma, or acute respiratory distress syndrome
- No return of spontaneous circulation or unstable circulation after 20 minutes of CPR, or restored circulation but unstable heart rhythm
- Signed informed consent
You will not qualify if you...
- Infectious diseases including hepatitis B, hepatitis C, AIDS, syphilis
- Blood disorders such as hematological malignancies, aplastic anemia, idiopathic thrombocytopenic purpura
- Malignant tumors outside the blood system
- Recent or massive plasma or platelet transfusions during hospitalization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fuwai Central China Cardiovascular Hospital
Zhengzhou, Henan, China
Actively Recruiting
Research Team
J
Jianchao Li
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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