Actively Recruiting
Plasma Extracellular Vesicles in Meningioma Patients
Led by University Hospital Heidelberg · Updated on 2026-03-10
60
Participants Needed
1
Research Sites
221 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring.
CONDITIONS
Official Title
Plasma Extracellular Vesicles in Meningioma Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed meningioma by histology or MRI/DOTATOC-PET CT
- Macroscopic tumor visible on MRI suitable for radiotherapy
- Indication for radiotherapy treatment
- Completed wound healing after any surgical intervention
- Age 18 years or older
- Karnofsky Performance Score of 60% or higher
- Provided written informed consent
- Ability to understand the nature and consequences of the trial
- Adequate contraception for women of childbearing potential
You will not qualify if you...
- History of other tumor diseases within the past 5 years
- Previous cerebral radiotherapy
- Receiving chemotherapy or immunotherapy at the same time
- Inability to follow the study protocol (e.g., non-compliance)
- Refusal to participate in the study
- Participation in another clinical study or observation in a competing trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital of Heidelberg, Radiation Oncology
Heidelberg, Germany, 69120
Actively Recruiting
Research Team
M
Max Deng, MD
CONTACT
A
Adriane Lentz-Hommertgen, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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