Study of Platelet Aggregation to Detect Acute Rejection in Adult Kidney Transplant Patients

What this Trial Is About

Researchers are investigating whether changes in platelet function can serve as non-invasive markers for detecting acute rejection in kidney transplant patients. This pilot observational study focuses on adult kidney transplant recipients, examining platelet aggregation and activation markers to understand their role in early kidney graft injury and immune response. The goal is to support diagnosis of acute cellular or antibody-mediated rejection alongside traditional biopsy methods. The study measures platelet function using optical aggregometry, flow cytometry for P-selectin expression, and soluble P-selectin levels. Two groups are observed patients undergoing routine protocol biopsies at 3 and 12 months post-transplant, and patients with signs of graft dysfunction who receive indication biopsies. Alongside platelet assessments, the study collects biochemical, immunological, and donor-specific antibody data to correlate with biopsy results. Participants undergo platelet testing before transplant and at scheduled biopsy times or when graft dysfunction is suspected. Researchers review platelet activation profiles, histopathology, and clinical outcomes to assess their potential as non-invasive diagnostic tools. The study involves longitudinal monitoring of renal function, immunosuppression levels, and metabolic parameters to provide a comprehensive understanding of graft health over time.

Platelet Aggregation in the Diagnosis of Acute Graft Rejection