Actively Recruiting
Platelet Aggregation in the Diagnosis of Acute Graft Rejection
Led by University Hospital, Martin · Updated on 2025-12-10
60
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study titled "Platelet Aggregation in the Diagnosis of Acute Graft Rejection" is a pilot observational study evaluating whether alterations in platelet function can serve as non-invasive markers of acute rejection in kidney transplant recipients. Platelet aggregation is assessed using optical aggregometry, flow-cytometric P-selectin (CD62-P) expression, and soluble P-selectin levels before kidney transplantation and at the time of protocol biopsies performed at 3 and 12 months after kidney transplantation. Patients with suspected graft dysfunction undergoing indication biopsy are also included. Platelet activation markers are correlated with histopathological findings, donor-specific antibodies, metabolic parameters, and clinical outcomes. The goal is to determine whether platelet activation profiles can identify acute cellular or antibody-mediated rejection and contribute to the development of a non-invasive diagnostic tool.
CONDITIONS
Official Title
Platelet Aggregation in the Diagnosis of Acute Graft Rejection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (18 years or older)
- Primary kidney transplantation
- Living or deceased donor kidney transplantation
- Ability and consent to participate
You will not qualify if you...
- Non-adult patients
- Secondary or tertiary kidney transplantation
- Use of antiplatelet therapy
- Patients unable to provide informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Transplant-Nephrology Department, University Hospital Martin
Martin, Slovakia, 03601
Actively Recruiting
Research Team
T
Timea Blichova, MD
CONTACT
P
Patricia Kleinova, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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