Actively Recruiting
Platelet-Directed Whole Blood Transfusion Strategy for Malaria
Led by Johns Hopkins Bloomberg School of Public Health · Updated on 2025-10-09
132
Participants Needed
2
Research Sites
222 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins Bloomberg School of Public Health
Lead Sponsor
J
Johns Hopkins University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Open-label randomized controlled trial to test the effectiveness of whole blood transfusion for improving survival in children with severe malaria complicated by thrombocytopenia.
CONDITIONS
Official Title
Platelet-Directed Whole Blood Transfusion Strategy for Malaria
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age under 5 years
- Platelet count of 75,000/uL or less
- Hemoglobin level greater than 5 and up to 9 g/dL
- P. falciparum parasitemia of 500 parasites/uL or more
- Diagnosis of severe malaria meeting WHO criteria
- Ability and willingness of legal guardian to comply with study protocol
- Residence within the health clinic catchment area
- Signed informed consent from parent or legal guardian
You will not qualify if you...
- Residence in foster care or under government supervision
- Residence outside the hospital catchment area or planned relocation
- Any condition that may compromise participant safety or data quality as judged by the investigator
- Any contraindication to whole blood transfusion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Johns Hopkins Bloomberg School of Public Health
Baltimore, Maryland, United States, 21205
Not Yet Recruiting
2
Tropical Diseases Research Centre
Ndola, Copperbelt, Zambia
Actively Recruiting
Research Team
M
Matthew M Ippolito, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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