Actively Recruiting
Platelet-Rich Fibrinogen in Extraction Socket Healing of the Aged
Led by University of Nebraska · Updated on 2026-01-27
12
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.
CONDITIONS
Official Title
Platelet-Rich Fibrinogen in Extraction Socket Healing of the Aged
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient at University of Nebraska Medical Center (UNMC) College of Dentistry
- Requires extraction of posterior tooth
- Able and willing to provide consent/assent
You will not qualify if you...
- Systemic conditions that delay wound healing
- Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates or other drugs that inhibit wound healing
- Smoking and vaping
- Pregnancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Nebraska Medical Center College of Dentistry
Lincoln, Nebraska, United States, 68358
Actively Recruiting
Research Team
A
Amy C Killeen, DDS, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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