Actively Recruiting
Wound Healing Outcomes in Aged Extraction Patients Using Platelet-Rich Fibrinogen
Led by University of Nebraska · Updated on 2026-01-27
12
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating oral wound healing in both younger and older participants after the removal of a posterior tooth. The study focuses on how platelet-rich fibrinogen (PRF) may affect healing in aged individuals compared to younger ones. This research includes participants aged 14 to 18 and 50 to 80 who need a tooth extraction for reasons like periodontal or endodontic defects, non-restorable caries, fractures, or orthodontic needs, and who may consider dental implants afterward. Participants will undergo a routine dental extraction, and some will receive PRF treatment applied to the extraction socket. After the extraction, small tissue samples will be collected from the site. The study involves four groups: young and aged participants both with and without PRF treatment. Follow-up visits include suture removal and tissue sampling two weeks post-extraction, and a final radiograph three months after to assess bone density and healing. Throughout the study, various assessments will be done including periodontal measurements, gingival fluid sampling, blood tests for hemoglobin A1C, and immunofluorescence analysis of tissue samples. Participants will have a baseline evaluation on the extraction day, a follow-up visit two weeks later, and a final visit at three months. The study aims to measure cytokine levels at baseline and two weeks post-extraction and evaluate bone density three months after the procedure.
CONDITIONS
Brief Title
Platelet-Rich Fibrinogen in Extraction Socket Healing of the Aged
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient at University of Nebraska Medical Center College of Dentistry
- Requires extraction of a posterior tooth
- Able and willing to provide consent or assent
You will not qualify if you...
- Systemic conditions that delay wound healing
- Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates, or other drugs that inhibit wound healing
- Smoking or vaping
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of extraction
Participants undergo routine atraumatic dental extraction. Those in the treatment groups receive Platelet-rich Fibrinogen (PRF) applied to the extraction socket immediately after the extraction.
1 visit (in-person)
Duration - Up to 3 months after extraction
Participants attend routine post-operative visits for suture removal, healing evaluation, and collection of tissue and fluid samples. Final assessment includes a cone-beam CT scan and clinical measurements to support implant planning and immunofluorescence processing.
3 visits (in-person) at 1, 2 or 3 weeks and 3 months post-extraction
Trial Site Locations
Total: 1 location
1
University of Nebraska Medical Center College of Dentistry
Lincoln, Nebraska, United States, 68358
Actively Recruiting
Research Team
A
Amy C Killeen, DDS, MS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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