Actively Recruiting
Platelet Rich Plasma for Insufficient Endometrium
Led by Reproductive Medicine Associates of New Jersey · Updated on 2025-02-07
62
Participants Needed
1
Research Sites
163 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To determine the effectiveness of an intrauterine PRP infusion on endometrial thickness and in vitro fertilization (IVF) outcomes in a population of infertile women with a history of unresponsive thin endometrium.
CONDITIONS
Official Title
Platelet Rich Plasma for Insufficient Endometrium
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who have previously undergone at least 2 unsuccessful frozen embryo transfer cycles, defined as failure to achieve a sustained clinical pregnancy (visualization of intrauterine gestational sac on ultrasound or a cancelled embryo transfer cycle due to inadequate endometrial thickness)
- Patients with a diagnosis of thin endometrial lining (less than or equal to 6 mm maximum thickness) during prior unsuccessful or canceled embryo transfer cycles.
You will not qualify if you...
- Fewer than 2 prior unsuccessful or canceled frozen embryo transfer cycles.
- Most recent unsuccessful embryo transfer prior to January 1, 2017.
- Mullerian anomalies, excluding arcuate uterus
- Concurrent submucosal fibroids, unrepaired uterine defects or present indication for uterine surgery
- Communicating hydrosalpinx without plans for surgical correction prior to study enrollment.
- Failure of patient to agree to enrollment in study with written consent.
- Concurrent pregnancy
- Anticoagulation use for which plasma infusion is contraindicated
- History of thrombosis
- Thrombophilia either inherited or acquired
- Concomitant use of adjunctive therapies for proliferation. These must be discontinued upon enrollment.
- Embryo planned to be used for transfer generated from surgically obtained sperm due to a diagnosis of non-obstructive azoospermia
- Recurrent/persistent endometrial fluid in prior cycles
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Reproductive Medicine Associates of New Jersey
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
Research Team
C
Christine V Whitehead, BSN, RN
CONTACT
C
Caroline Zuckerman, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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