A Study Testing Platelet-Rich Plasma Injections to Treat Peyronies Disease in Men

What this Trial Is About

Researchers are evaluating the effects of Platelet-Rich Plasma PRP injections in men diagnosed with Peyronies disease PD during its fibrotic phase. The study aims to assess how PRP may influence penile curvature and other related symptoms compared to a placebo treatment. A total of 84 male participants with specific degrees of penile curvature will be involved in this randomized, double-blind clinical trial. Participants are divided into two groups based on their penile curvature severity and randomized to receive either PRP or saline solution injections. Each participant will undergo weekly intralesional injections of 6 mL either PRP or saline for three weeks. Alongside the injections, all participants will perform daily penile stretching exercises from the first injection until the three-month follow-up. The trial includes a baseline visit, a three-month post-treatment follow-up, and additional long-term assessments at six and twelve months. Throughout the study, participants will have their penile curvature measured and evaluated at multiple points, including 12 months after treatment. Other outcomes assessed include plaque size, erectile hardness, depressive symptoms, ability to engage in sexual intercourse, preference for surgery, and global assessment scales. Data collection involves questionnaires, medical records, and physical examinations. This follow-up schedule allows researchers to monitor changes over time and analyze the effectiveness and safety of PRP treatment in this condition.

Platelet-Rich Plasma for Peyronie's Disease