Actively Recruiting
Platelet Rich Plasma Testis Treatment for Infertile Men
Led by Stanford University · Updated on 2026-01-13
10
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the use of autologous platelet rich plasma (PRP) injections into the testes to improve sperm retrieval rates and in vitro fertilization (IVF) outcomes in infertile men who have previously had unsuccessful testicular sperm extraction (TESE). This study focuses on men with nonobstructive azoospermia (NOA) who have already experienced negative sperm retrieval, as there are currently no alternative treatments after failed TESE. Participants will have blood drawn to prepare the PRP infusion using a centrifuge and an Arteriocyte Magellan kit. After local anesthesia, the PRP is injected into each testicle. Three months after this procedure, another TESE will be performed. If successful, the sperm obtained will be used in a new IVF cycle. During the study, participants will be monitored for sperm presence three months after the PRP injection as the primary outcome. The process includes the blood draw, PRP injection, and follow-up TESE. The study is sponsored by Stanford University and participation involves visits for treatment and evaluation within a timeframe up to the end of 2026.
CONDITIONS
Brief Title
Platelet Rich Plasma Testis Treatment for Infertile Men
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male participants aged 18 years or older
- Diagnosed with nonobstructive azoospermia (NOA)
- At least one prior failed testicular sperm extraction (TESE), negative mapping, or negative biopsy
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment visit with follow-up assessments over 3 months
Participants receive a blood draw to prepare platelet rich plasma (PRP), followed by local anesthesia and PRP injection into each testicle.
1 treatment visit and follow-up assessments up to 3 months
Duration - Assessment at 3 months after PRP injection
At 3 months post-PRP injection, participants undergo testicular sperm extraction (TESE). If successful, a new IVF cycle using the procured sperm will be conducted.
1 visit at 3 months post-treatment
Trial Site Locations
Total: 1 location
1
Stanford Urology Clinic
Stanford, California, United States, 94304
Actively Recruiting
Research Team
S
Satvir Basran
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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