Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective.
Rachita Dhurat, Ms Sukesh
https://pubmed.ncbi.nlm.nih.gov/25722595Actively Recruiting
Phase Not Applicable
Age: 18Years - 52Years
FEMALE
Healthy Volunteers
ID05224726
Platelet Rich Plasma for the Treatment of Uterine Scar to Improve Healing After Cesarean Delivery
Led by The University of Texas Health Science Center, Houston · Updated on 2025-08-26
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center, Houston
Lead Sponsor
S
Sheba Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the use of platelet-rich plasma (PRP) to improve healing of uterine scars in women undergoing elective cesarean delivery. PRP contains growth factors that support wound healing and inflammation control. The study aims to understand whether PRP can reduce complications associated with uterine scar defects, such as pelvic pain, irregular bleeding, and fertility issues, which have increased with the rising rate of cesarean deliveries. Participants will be randomly assigned to receive an injection of either PRP or a placebo (normal saline) into the myometrium around the uterine incision after the first layer of suturing during cesarean delivery. Blood will be drawn prior to surgery to prepare the PRP for those randomized to that group. The study is double-blinded, so participants will not know their assigned treatment. Follow-up visits will occur at six weeks, three months, and six months after delivery. During follow-up, participants will undergo trans-vaginal ultrasound scans to measure characteristics of the uterine scar, including depth, residual myometrial thickness, and scar dimensions. Researchers will also collect reports of symptoms like heavy bleeding, spotting, and pelvic pain. Operative and postoperative data will be recorded, including complications and recovery details. The primary outcome is the depth of the uterine scar measured at each follow-up visit.
CONDITIONS
Brief Title
Platelet Rich Plasma for Uterine Scar
Who Can Participate
Age: 18Years - 52Years
FEMALE
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Women undergoing elective cesarean delivery
- Term pregnancy (≥37 weeks of gestation)
- Female gender
- Age between 18 and 52 years
You will not qualify if you...
- Platelet count less than 70,000 (thrombocytopenia)
- Connective tissue disease
- Uterine scars from surgeries other than cesarean delivery (e.g., myomectomy, cornual resection)
- Malformed uterus (unicornuate, bicornuate, didelphic)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Day of cesarean delivery
Participants undergo elective cesarean delivery. During the operation, a blood sample is drawn for platelet count and preparation of platelet rich plasma (PRP) or placebo injection around the uterine incision after closure of the first layer.
1 visit (in-person)
Post-operative Follow-up
Duration - 6 months
Participants attend gynecologic clinic visits for trans-vaginal sonographic evaluation of the uterine scar and report on uterine scar symptoms such as heavy menstrual bleeding, intermenstrual spotting, and pelvic pain.
3 visits (at 6 weeks, 3 months, and 6 months post-operation, in-person)
Trial Site Locations
Total: 1 location
1
Sheba Medical Center
Ramat Gan, Center, Israel, 55030
Actively Recruiting
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Research Team
A
Aya A Mohr-Sasson, M.D
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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