Using Platelet Rich Plasma to Improve Healing of Uterine Scars After Cesarean Delivery

What this Trial Is About

Researchers are evaluating the use of platelet-rich plasma PRP to improve healing of uterine scars in women undergoing elective cesarean delivery. PRP contains growth factors that support wound healing and inflammation control. The study aims to understand whether PRP can reduce complications associated with uterine scar defects, such as pelvic pain, irregular bleeding, and fertility issues, which have increased with the rising rate of cesarean deliveries. Participants will be randomly assigned to receive an injection of either PRP or a placebo normal saline into the myometrium around the uterine incision after the first layer of suturing during cesarean delivery. Blood will be drawn prior to surgery to prepare the PRP for those randomized to that group. The study is double-blinded, so participants will not know their assigned treatment. Follow-up visits will occur at six weeks, three months, and six months after delivery. During follow-up, participants will undergo trans-vaginal ultrasound scans to measure characteristics of the uterine scar, including depth, residual myometrial thickness, and scar dimensions. Researchers will also collect reports of symptoms like heavy bleeding, spotting, and pelvic pain. Operative and postoperative data will be recorded, including complications and recovery details. The primary outcome is the depth of the uterine scar measured at each follow-up visit.

Platelet Rich Plasma for Uterine Scar