Actively Recruiting
Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion
Led by Mayo Clinic · Updated on 2026-03-30
60
Participants Needed
1
Research Sites
100 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to see if there is any benefit in adding saline irrigation through a chest tube to the standard course of treatment for people diagnosed or suspected of having a pleural space infection.
CONDITIONS
Official Title
Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Purulent pleural fluid or pleural fluid with pH less than 7.2, glucose less than 60 mg/dL, positive Gram stain, or positive culture, or a multiseptated pleural effusion suspected to be infected
- Starting intrapleural lytic therapy under care of the Interventional Pulmonary service at Mayo Clinic in Rochester, MN
- Age 18 years or older
You will not qualify if you...
- Unwilling to give informed consent
- Known bleeding disorder
- Platelet count less than 50,000 per microliter
- INR greater than 2.2 (may be reversed before treatment)
- Using systemic anticoagulation or antiplatelet therapy that cannot be safely stopped before procedure (aspirin alone allowed)
- Pregnant or nursing women or women of childbearing potential who refuse pregnancy testing
- Incarcerated patients
- Presence of bronchopleural fistula on the affected side
- Current or recent tunneled pleural catheter on the same side as the infection within past 30 days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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