Actively Recruiting
Peri-incisional Local Infiltration to Improve Pain Control After Periacetabular Osteotomy Surgery for Hip Dysplasia
Led by Michael C Willey · Updated on 2026-04-17
120
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
Sponsors
M
Michael C Willey
Lead Sponsor
N
Northwestern University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating peri-incisional local infiltrative anesthesia (PLIA) methods in patients aged 13 to 50 undergoing periacetabular osteotomy (PAO) for hip dysplasia. The study aims to determine if PLIA affects post-operative pain and pain medication use, and whether the timing of PLIA administration influences these outcomes. Participants will complete surveys including demographics, self-efficacy, and pain resilience scores, while other data will be collected from medical records. Participants are randomly assigned to one of three groups: no PLIA (standard care pain management), PLIA administered after incision closure using a pediatric catheter, or PLIA administered throughout the surgical procedure. The PLIA consists of a combination of ropivacaine, epinephrine, ketorolac, and saline, with dosing adjusted based on patient weight. All groups receive the same standard post-operative pain medications as needed. Patients will be approached at their preoperative appointment to consent and complete surveys via tablet or computer. Postoperative pain levels and narcotic use will be tracked through medical record review until hospital discharge, typically about three days. The primary outcomes include pain scores in the Post Anesthesia Care Unit and up to 24 hours and medication use during the hospital stay. Secondary outcomes assess depression, self-efficacy, and pain resilience before surgery. Participants remain blinded to their group until their three-month follow-up visit.
CONDITIONS
Brief Title
Can PLIA Reduce Early Post-operative Pain After PAO Surgery?
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adolescent or young adult diagnosed with hip dysplasia indicated for periacetabular osteotomy at University of Iowa Hospital and Clinics
You will not qualify if you...
- Unable to provide informed consent
- Pregnant or breast-feeding individuals
- Prisoner or ward of the state
- Allergy or medical contradiction to any of the study medications
- Patients undergoing femoral osteotomy or surgical hip dislocation with periacetabular osteotomy will be excluded
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) at preoperative appointment
Duration - Hospital stay averaging 3 days
Participants undergo periacetabular osteotomy surgery. Depending on their group, they may receive peri-incisional local infiltration anesthesia (PLIA) either throughout the procedure, after incision closure, or no PLIA. All participants receive standard pain medications after surgery.
Surgery day and continuous hospital monitoring until discharge
Duration - Up to 3 months
Participants' pain levels and medication use are monitored until hospital discharge. Additional pain and outcome assessments occur at standard-of-care follow-up visits, including a 3-month visit where participants may learn their treatment group.
1 standard-of-care follow-up visit at 3 months
Trial Site Locations
Total: 1 location
1
University of Iowa Health Care
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
A
Ashley S Kochuyt
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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