Actively Recruiting

Phase 1
Phase 2
Age: 18Years - 75Years
All Genders
NCT05918445

PM8002 in the Treatment of Patients With Advanced Solid Tumors

Led by Biotheus Inc. · Updated on 2024-12-05

380

Participants Needed

48

Research Sites

246 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study is to characterize the safety, tolerability, pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD) and anti-tumor activity of PM8002, a PD-L1/VEGF bispecific antibody, as a single agent in adult subjects with advanced solid tumors.

CONDITIONS

Official Title

PM8002 in the Treatment of Patients With Advanced Solid Tumors

Who Can Participate

Age: 18Years - 75Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Voluntary participation with informed consent and ability to complete all study procedures
  • Male or female aged 18 to 75 years
  • Histologically or cytologically confirmed malignant tumor
  • Toxicity from previous anti-tumor therapy not alleviated
  • Adequate organ function
  • ECOG performance status of 0 to 1
  • Expected survival of at least 12 weeks
  • At least one measurable lesion not previously treated locally per RECIST 1.1 criteria
Not Eligible

You will not qualify if you...

  • History of severe allergic disease or known allergy to study drug components
  • Major coagulopathy or significant bleeding risk
  • Active interstitial lung disease or non-infectious pneumonia, unless caused by local radiotherapy
  • Uncontrolled brain metastases
  • Other active malignant tumors within 5 years prior to treatment
  • Prior allogeneic organ or hematopoietic stem cell transplantation
  • History of alcohol, psychotropic drug, or drug abuse
  • Positive for syphilis antibody
  • Active tuberculosis
  • Pregnant or lactating women
  • Any other condition making participation inappropriate as judged by the investigator

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 48 locations

1

Baoji Central Hospital

Baoji, China

Actively Recruiting

2

Baoji Central Hospital

Baoji, China

Actively Recruiting

3

Cancer Hospital Chinese Academy of Medical Sciences

Beijing, China

Actively Recruiting

4

Peking University Cancer Hospital

Beijing, China

Actively Recruiting

5

Peking University Cancer Hospital

Beijing, China

Actively Recruiting

6

Jilin Cancer Hospital

Changchun, China

Actively Recruiting

7

The First Hospital of Jilin University

Changchun, China

Actively Recruiting

8

Changde First People's Hospital

Changde, China

Actively Recruiting

9

Hunan Provincial People's Hospital

Changsha, China

Actively Recruiting

10

The First People's Hospital of Changzhou

Changzhou, China

Actively Recruiting

11

Chengdu Integrated TCM& Western Medicine Hospital

Chengdu, China

Actively Recruiting

12

Sichuan Cancer Hospital

Chengdu, China

Actively Recruiting

13

Chongqing Cancer Hospital

Chongqing, China

Actively Recruiting

14

Chongqing Cancer Hospital

Chongqing, China

Actively Recruiting

15

The First Affiliated Hospital of Chongqing Medical University

Chongqing, China

Actively Recruiting

16

The Southwest Hospital of AMU

Chongqing, China

Actively Recruiting

17

Fujian Cancer Hospital

Fuzhou, China

Actively Recruiting

18

Fujian Cancer Hospital

Fuzhou, China

Actively Recruiting

19

Zhejiang Provincial People's Hospital

Hangzhou, China

Actively Recruiting

20

Harbin Medical University Cancer Hospital

Harbin, China

Actively Recruiting

21

Anhui Provincial Hospital

Hefei, China

Actively Recruiting

22

Linyi Cancer Hospital

Linyi, China

Actively Recruiting

23

Jiangsu Province Hospital

Nanjing, China

Actively Recruiting

24

Jiangsu Province Hospital

Nanjing, China

Actively Recruiting

25

Shanghai Orient Hospital

Shanghai, China

Actively Recruiting

26

Shanghai Sixth People's Hospital

Shanghai, China

Actively Recruiting

27

Shengjing Hospital of China Medical University

Shengjing, China

Actively Recruiting

28

Liaoning Cancer Hospital

Shenyang, China

Actively Recruiting

29

The First Hospital of China Medical University

Shenyang, China

Actively Recruiting

30

The People's Hospital of Liaoning Province

Shenyang, China

Actively Recruiting

31

The Fourth Hospital of Hebei Medical University

Shijiazhuang, China

Actively Recruiting

32

Shanxi Bethune Hospital

Taiyuan, China

Actively Recruiting

33

Shanxi Provincial Cancer Hospital

Taiyuan, China

Actively Recruiting

34

Shanxi Provincial Cancer Hospital

Taiyuan, China

Actively Recruiting

35

Taizhou Hospital of Zhejiang Province

Taizhou, China

Actively Recruiting

36

The Second Hospital of Tianjin Medical University

Tianjin, China

Actively Recruiting

37

Hubei Cancer Hospital

Wuhan, China

Actively Recruiting

38

Hubei Cancer Hospital

Wuhan, China

Actively Recruiting

39

Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, China

Actively Recruiting

40

The First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, China

Actively Recruiting

41

Xi 'an International Medical Center Hospital

Xi'an, China

Actively Recruiting

42

Xi 'an International Medical Center Hospital

Xi'an, China

Actively Recruiting

43

Yantai Yuhuangding Hospital

Yantai, China

Actively Recruiting

44

Yibin Second People's Hospital

Yibin, China

Actively Recruiting

45

Henan Cancer Hospital

Zhengzhou, China

Actively Recruiting

46

The first affilated hospital of zhengzhou university

Zhengzhou, China

Actively Recruiting

47

The first affilated hospital of zhengzhou university

Zhengzhou, China

Actively Recruiting

48

Zhujiang Hospital of Southern Medical University

Zhujiang, China

Actively Recruiting

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Research Team

Y

Ye Guo

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SEQUENTIAL

Primary Purpose

TREATMENT

Number of Arms

1

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PM8002 in the Treatment of Patients With Advanced Solid Tumors | DecenTrialz