Actively Recruiting
PMI Guide PS Setting in Pressure Support-ventilated Patients
Led by Capital Medical University · Updated on 2025-01-09
60
Participants Needed
1
Research Sites
126 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pressure support ventilation (PSV) is an assistant mechanical ventilation mode, that is widely implemented in mechanical ventilation treatment but there are no exact guidelines to guide PS setting. Traditional PS setting strategy (VT/PBW 6-8ml/kg and RR 20-30 breaths/min)has risks of excessive or insufficient assistance. Inspiratory muscle pressure index (PMI) is a noninvasive respiratory mechanical indicator and is available at the bedside. PMI was correlated with inspiratory effort and has the potential ability to predict low inspiratory effort and high inspiratory effort. The primary objective of this study is to investigate the clinical validity of a PMI-guided PS setting strategy. Specifically, the investigators aim to evaluate its impact on inspiratory effort as well as its potential for lung and diaphragm protection. Additionally, the investigators seek to assess the effect of this ventilation strategy on mechanical ventilation outcomes while evaluating the feasibility of our trial protocol.
CONDITIONS
Official Title
PMI Guide PS Setting in Pressure Support-ventilated Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients under pressure support ventilation (PSV)
- Predicted ventilated time of more than 48 hours
You will not qualify if you...
- Age less than 18 years
- Known pregnancy
- Body mass index (BMI) greater than 35 kg/m2
- Brain-stem or cervical spinal cord injury
- Known or suspected elevated intracranial pressure (greater than 18 mmHg)
- Injury to the phrenic nerve or diaphragm
- Broncho-pleural fistula
- Chronic obstructive pulmonary disease (COPD)
- Pressure support ventilation for more than 48 hours before randomization
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100071
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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