Actively Recruiting
The Effect of Professional Mechanical Plaque Removal (PMPR) and Chlorhexidine Mouthwash on Salivary and Acquired Enamel Pellicle (AEP) Proteins and Vascular Function and Inflammation in People With Periodontal Disease
Led by Mahdi Mutahar · Updated on 2026-03-25
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Mahdi Mutahar
Lead Sponsor
L
Loughborough University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying periodontal disease (PD), a chronic gum inflammation that can also affect bone and ligaments supporting teeth. This condition is linked to increased risk of heart disease and other health issues. The study focuses on how professional deep cleaning (PMPR), with or without chlorhexidine (CHX) mouthwash, affects proteins in saliva and a protective tooth coating called the salivary pellicle, as well as blood vessel function in people with gum disease. Participants receive PMPR treatment using ultrasonic scalers at the start of the study. Then, they are randomly assigned to use either a 0.2% chlorhexidine mouthwash or a placebo mouthwash twice daily for 14 days. Saliva, blood samples, and vascular health tests are done at baseline, Day 1, Day 14, and Day 90, to examine changes in oral bacteria, proteins, and blood vessel function after treatments. During the study, participants undergo saliva collection, dental exams, and measures of blood vessel health such as ultrasound and blood pressure tests at multiple visits over three months. Researchers analyze saliva proteins, oral bacteria, and blood markers of inflammation to understand how treatments may influence oral and cardiovascular health. The total participation time is about 90 days, with safety and vascular function monitored throughout.
CONDITIONS
Brief Title
PMPR and Chlorhexidine on Periodontal Disease and Vascular Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have at least 12 natural teeth, with a minimum of 2 teeth in each sextant of the mouth
- Diagnosed with gingivitis and/or early stage periodontal disease (stage 1 or 2)
- No periodontal maintenance therapy (PMPR) within the last 6 months
- Not currently wearing fixed or removable orthodontic appliances
- No antibiotic treatments in the last 3 months
- Able to provide written informed consent
- Individuals with dental erosion or caries are eligible but will be matched at baseline
You will not qualify if you...
- Taking regular medication within 1 month before study start for any medical condition such as hypertension or diabetes
- Pregnant or breastfeeding
- Non-English speakers or requiring an interpreter
- Unable to provide written informed consent
- Participating in another clinical study (except observational) within 3 months before or during this study
- Used mouthwash or tongue scrapers within the last 6 weeks
- Smokes 20 or more cigarettes per day
- Consumes more than 5 alcoholic drinks per day
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for oral screening and consent
Duration - Day 0 (single day)
Participants receive routine PMPR treatment for gingivitis and periodontal disease as part of standard care.
1 baseline visit (in-person) including PMPR and initial assessments
Duration - 14 days
Participants use either 0.2% chlorhexidine mouthwash or placebo mouthwash twice daily for 14 days following PMPR to study effects on oral and vascular health.
1 visit on Day 1 for randomization and treatment start; daily mouthwash use at home
Duration - Up to 3 months post-PMPR
Participants undergo saliva, blood, and vascular function assessments to monitor changes after treatment and over time.
3 visits on Day 1, Day 14, and Day 90 for sample collection and vascular tests
Trial Site Locations
Total: 1 location
1
University of Portsmouth
Portsmouth, Hampshire, United Kingdom, PO1 2QG
Actively Recruiting
Research Team
M
Mahdi Mutahar, PhD
S
Saagarika Sharma
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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