Study of Deep Cleaning and Chlorhexidine Mouthwash Effects on Saliva Proteins and Blood Vessel Health in Adults with Gum Disease

What this Trial Is About

Researchers are studying periodontal disease PD, a chronic gum inflammation that can also affect bone and ligaments supporting teeth. This condition is linked to increased risk of heart disease and other health issues. The study focuses on how professional deep cleaning PMPR, with or without chlorhexidine CHX mouthwash, affects proteins in saliva and a protective tooth coating called the salivary pellicle, as well as blood vessel function in people with gum disease. Participants receive PMPR treatment using ultrasonic scalers at the start of the study. Then, they are randomly assigned to use either a 0.2% chlorhexidine mouthwash or a placebo mouthwash twice daily for 14 days. Saliva, blood samples, and vascular health tests are done at baseline, Day 1, Day 14, and Day 90, to examine changes in oral bacteria, proteins, and blood vessel function after treatments. During the study, participants undergo saliva collection, dental exams, and measures of blood vessel health such as ultrasound and blood pressure tests at multiple visits over three months. Researchers analyze saliva proteins, oral bacteria, and blood markers of inflammation to understand how treatments may influence oral and cardiovascular health. The total participation time is about 90 days, with safety and vascular function monitored throughout.

PMPR and Chlorhexidine on Periodontal Disease and Vascular Function