Actively Recruiting
Pneumatic Leg Compression and Norepinephrine Requirements in Patients Having Non-cardiac Surgery
Led by Universitätsklinikum Hamburg-Eppendorf · Updated on 2025-06-08
238
Participants Needed
1
Research Sites
19 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The PLANE trial is a randomized, single-center trial investigating whether pneumatic leg compression reduces the amount of norepinephrine needed to keep MAP above 65mmHg compared to routine care without PLC in patients having non-cardiac surgery under general anesthesia
CONDITIONS
Official Title
Pneumatic Leg Compression and Norepinephrine Requirements in Patients Having Non-cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
Consenting patients ≥45 years scheduled for elective non-cardiac surgery under general anesthesia that is expected to last ≥60 minutes
You will not qualify if you...
Patients with the following exclusion criteria:
- Surgery in which pneumatic calve compression is indicated according to ERAS guidelines
- Surgery which interferes with the installation or correct function of PLC
- Sepsis (according to current Sepsis-3 definition)
- Pregnancy
- Congestive heart failure NYHA III/IV
- American Society of Anesthesiologists (ASA) physical status classification V or VI
- Interference of PLC and patient positioning (e.g.; extreme Trendelenburg positioning, lithotomy positioning)
- Contraindications for the use of PLC according to the German guideline13 (e.g., extensive thrombophlebitis, thrombosis or suspected thrombosis of the lower limbs, erysipelas, acute phlegmon, limb compartment syndrome, severe uncontrolled arterial hypertension, lymphatic drainage disorder proximal to PLC, extensive open soft tissue trauma, autoimmune blistering skin conditions such as IgA bullous dermatosis or bullous pemphigoid)
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Medical Center Hamburg-Eppendorf
Hamburg, Free and Hanseatic City of Hamburg, Germany, 20246
Actively Recruiting
Research Team
D
Dominik Müller
CONTACT
B
Bernd Saugel, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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