Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06921603

POCUS-Guided Diuresis for Decompensated Heart Failure

Led by University of Pittsburgh · Updated on 2026-02-17

588

Participants Needed

5

Research Sites

74 weeks

Total Duration

On this page

Sponsors

U

University of Pittsburgh

Lead Sponsor

A

American Heart Association

Collaborating Sponsor

AI-Summary

What this Trial Is About

Heart failure occurs when the heart cannot pump blood effectively, leading to fluid buildup in the body. This can cause problems such as difficulty breathing, swelling, and extreme tiredness. In severe cases, these symptoms worsen to the point where hospitalization is required. Unfortunately, many patients with severe heart failure are readmitted to the hospital within 30 days after discharge, which is both physically and emotionally challenging for patients and places a significant financial burden on individuals and the healthcare system. Although symptoms such as difficulty breathing and swelling may improve during the hospital stay, some patients are discharged with excess fluid remaining in their bodies. This retained fluid often causes symptoms to worsen, leading to subsequent hospital readmissions. Inadequate management of fluid levels can also harm the kidneys, further complicating the patient's condition. This study aims to improve care for heart failure patients by utilizing a simple, non-invasive tool to assess fluid levels more accurately at the bedside. The tool measures the size of a large blood vessel in the neck, providing key information about the pressure inside the heart. This information enables clinicians to determine the appropriate amount of medication needed to remove just the right amount of fluid. Properly managing fluid levels can help prevent kidney damage and improve overall patient outcomes. The primary goal of this study is to evaluate whether this tool can reduce the number of patients readmitted to the hospital within 30 days of discharge. A secondary goal is to determine whether the tool can help protect kidney function by allowing for better fluid management. If successful, this approach has the potential to help heart failure patients stay healthier, reduce hospital visits, and lower healthcare costs.

CONDITIONS

Official Title

POCUS-Guided Diuresis for Decompensated Heart Failure

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients must be 18 years or older.
  • Confirmed diagnosis of acute decompensated heart failure (ADHF).
  • Planned treatment with intravenous diuretics.
  • Abnormal right internal jugular vein distensibility index (DI) less than 66% on point-of-care ultrasound at admission.
Not Eligible

You will not qualify if you...

  • Presence of left ventricular assist devices (LVAD).
  • Thrombus in the right internal jugular vein or superior vena cava, congenital heart disease, or severe tricuspid regurgitation.
  • Diagnosis of hypertrophic or infiltrative cardiomyopathy.
  • Receiving hospice care or comfort measures only.
  • Metastatic cancer.
  • Severe liver dysfunction with MELD-Na score greater than 20.
  • End stage chronic kidney disease.
  • Unable to provide informed consent.
  • Requiring inotropic support at enrollment.

AI-Screening

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Trial Site Locations

Total: 5 locations

1

UPMC East

Pittsburgh, Pennsylvania, United States, 15146

Not Yet Recruiting

2

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States, 15213

Actively Recruiting

3

UPMC Presbyterian

Pittsburgh, Pennsylvania, United States, 15213

Actively Recruiting

4

UPMC Mercy

Pittsburgh, Pennsylvania, United States, 15219

Not Yet Recruiting

5

UPMC Shadyside

Pittsburgh, Pennsylvania, United States, 15232

Actively Recruiting

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Research Team

J

John J Pacella, MD

CONTACT

B

Benay Ozbay, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

DIAGNOSTIC

Number of Arms

2

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