Hyponatremia and mortality among patients on the liver-transplant waiting list.
W Ray Kim, Scott W Biggins, Walter K Kremers...
https://pubmed.ncbi.nlm.nih.gov/18768945/Actively Recruiting
Led by University of Pittsburgh · Updated on 2026-02-17
588
Participants Needed
5
Research Sites
N/A
Total Duration
Heart failure happens when the heart struggles to pump blood effectively, causing fluid buildup that leads to symptoms like trouble breathing, swelling, and fatigue. This condition often results in hospital stays, and many patients are readmitted within 30 days after leaving. This study evaluates a new, simple bedside tool that uses ultrasound to measure fluid levels more accurately in patients with acute decompensated heart failure, aiming to reduce hospital readmissions and protect kidney function. The study compares two groups of patients hospitalized with acute decompensated heart failure. One group will have their fluid status monitored daily with point-of-care ultrasound POCUS, which measures the size and flexibility of a large vein in the neck to estimate heart pressure and guide diuretic medication doses. The other group will receive standard intravenous diuretic treatment based on usual clinical assessments, with ultrasound performed only for research and not guiding care. Both groups receive intravenous furosemide, a common diuretic, during their hospital stay. Participants will be closely monitored from admission through discharge and up to 30 days after leaving the hospital. Assessments include daily ultrasound scans to measure fluid status, kidney function tests, and tracking of hospital readmissions and mortality. The study will also evaluate how well clinicians follow ultrasound-guided recommendations and the length of hospital stays. Overall, this research aims to improve fluid management, reduce kidney injury, and decrease the chance of patients needing to return to the hospital soon after discharge.
CONDITIONS
POCUS-Guided Diuresis for Decompensated Heart Failure
J
John J Pacella, MD
B
Benay Ozbay, MD
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University of Pittsburgh
Lead Sponsor
American Heart Association
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | POCUS-Guided Diuretic Management | Standard Clinical Assessment |
|---|---|---|
| What it is | A strategy where point-of-care ultrasound (POCUS) of the right internal jugular vein (RIJV) is used to measure vein distensibility, and these findings are shared with the treating clinical team to help guide intravenous diuretic therapy for acute decompensated heart failure. | Management of fluid overload in acute decompensated heart failure using intravenous furosemide, with all treatment decisions based on routine clinical assessment (symptoms, physical exam, lab results), without POCUS results being available to the treating team. |
| Primary use | To provide objective information about central venous pressure and volume status, potentially improving decision making around diuretic dosing to minimize readmission and kidney injury. | To manage acute fluid overload using established assessment methods and intravenous diuretics according to standard clinical practice. |
| How it is given or performed | Daily non-invasive ultrasound measures the right internal jugular vein size and distensibility. Results are shared with the team and factored into diuretic dosing and discharge planning. All final decisions are made by the treating physicians. | Participants receive intravenous furosemide as determined by standard practice, with decisions based on symptoms, physical findings, and laboratory results. POCUS data is collected for research purposes but is not shared with the treating team. |
| Evidence status | Published studies and systematic reviews show that jugular venous ultrasound is a promising tool for volume assessment, but its direct clinical benefit (such as reduced readmission rates or acute kidney injury) has not been definitively established in large randomized trials. | Standard diuretic management using routine clinical assessment is extensively supported by guideline recommendations and long-standing clinical experience for acute decompensated heart failure. |
| Important limitations | The impact of POCUS-guided therapy on reducing heart failure readmissions or kidney injury remains unproven; accuracy may be limited by technical factors or anatomical variations, and the approach requires operator skill with jugular vein imaging. | Traditional assessment of fluid status in heart failure relies on clinical signs and symptoms, which may sometimes be inaccurate or miss subclinical congestion, potentially impacting patient management. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of hospital stay (up to 60 days)
Participants receive intravenous diuretic treatment guided either by point-of-care ultrasound (POCUS) assessments of volume status or by standard clinical evaluations. Daily POCUS imaging is performed for research or treatment guidance depending on the assigned group. Treatment decisions and discharge planning are based on clinical assessments with or without POCUS information.
Daily visits during hospitalization
Duration - Up to 30 days post-discharge
Participants are monitored for readmission, acute kidney injury, and mortality for 30 days after hospital discharge.
Follow-up assessments up to 30 days
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/19215833/University of Pittsburgh
Lead Sponsor
American Heart Association
Collaborating Sponsor