Actively Recruiting
POCUS-Guided Diuresis for Decompensated Heart Failure
Led by University of Pittsburgh · Updated on 2026-02-17
588
Participants Needed
5
Research Sites
74 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
A
American Heart Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
Heart failure occurs when the heart cannot pump blood effectively, leading to fluid buildup in the body. This can cause problems such as difficulty breathing, swelling, and extreme tiredness. In severe cases, these symptoms worsen to the point where hospitalization is required. Unfortunately, many patients with severe heart failure are readmitted to the hospital within 30 days after discharge, which is both physically and emotionally challenging for patients and places a significant financial burden on individuals and the healthcare system. Although symptoms such as difficulty breathing and swelling may improve during the hospital stay, some patients are discharged with excess fluid remaining in their bodies. This retained fluid often causes symptoms to worsen, leading to subsequent hospital readmissions. Inadequate management of fluid levels can also harm the kidneys, further complicating the patient's condition. This study aims to improve care for heart failure patients by utilizing a simple, non-invasive tool to assess fluid levels more accurately at the bedside. The tool measures the size of a large blood vessel in the neck, providing key information about the pressure inside the heart. This information enables clinicians to determine the appropriate amount of medication needed to remove just the right amount of fluid. Properly managing fluid levels can help prevent kidney damage and improve overall patient outcomes. The primary goal of this study is to evaluate whether this tool can reduce the number of patients readmitted to the hospital within 30 days of discharge. A secondary goal is to determine whether the tool can help protect kidney function by allowing for better fluid management. If successful, this approach has the potential to help heart failure patients stay healthier, reduce hospital visits, and lower healthcare costs.
CONDITIONS
Official Title
POCUS-Guided Diuresis for Decompensated Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must be 18 years or older.
- Confirmed diagnosis of acute decompensated heart failure (ADHF).
- Planned treatment with intravenous diuretics.
- Abnormal right internal jugular vein distensibility index (DI) less than 66% on point-of-care ultrasound at admission.
You will not qualify if you...
- Presence of left ventricular assist devices (LVAD).
- Thrombus in the right internal jugular vein or superior vena cava, congenital heart disease, or severe tricuspid regurgitation.
- Diagnosis of hypertrophic or infiltrative cardiomyopathy.
- Receiving hospice care or comfort measures only.
- Metastatic cancer.
- Severe liver dysfunction with MELD-Na score greater than 20.
- End stage chronic kidney disease.
- Unable to provide informed consent.
- Requiring inotropic support at enrollment.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 5 locations
1
UPMC East
Pittsburgh, Pennsylvania, United States, 15146
Not Yet Recruiting
2
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
3
UPMC Presbyterian
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
4
UPMC Mercy
Pittsburgh, Pennsylvania, United States, 15219
Not Yet Recruiting
5
UPMC Shadyside
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
Research Team
J
John J Pacella, MD
CONTACT
B
Benay Ozbay, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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