Actively Recruiting
POLA-R-CHP in the First-line Treatment of Transformed DLBCL
Led by Fudan University · Updated on 2025-02-25
20
Participants Needed
1
Research Sites
249 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate efficacy and safety of POLA-R-CHP in the treatment of patients with transformed DLBCL.
CONDITIONS
Official Title
POLA-R-CHP in the First-line Treatment of Transformed DLBCL
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 80 years old
- Histologically confirmed transformed diffuse large B-cell lymphoma (DLBCL)
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
- Signed informed consent form
- Adequate organ function including hematopoietic, liver, renal function, and heart function (left ventricular ejection fraction ≥ 50%)
You will not qualify if you...
- Allergy or sensitivity to human or mouse monoclonal antibodies or murine products
- Previous organ transplantation
- Prior treatment with cytotoxic drugs within 5 years or prior use of anti-CD20 antibodies
- Uncontrolled significant cardiovascular or pulmonary diseases
- Major surgery within 4 weeks before enrollment (except diagnostic surgery)
- Active infections or recent major infections within 2 weeks before treatment start
- Previous radiotherapy in the mediastinum or pericardial region
- Active chronic hepatitis B infection or positive HBV DNA without proper management
- Positive hepatitis C antibody with detectable HCV RNA
- Active HIV or syphilis infections
- Pregnant or lactating women
- Investigator’s judgment deeming the patient unsuitable for participation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China, 200032
Actively Recruiting
Research Team
Y
Yizhen Liu, M.D., Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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