Actively Recruiting
Poly-L-Lactic Acid in Atrophic Acne Scars
Led by Zagazig University · Updated on 2026-04-13
52
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Management of atrophic acne scars remains challenging due to their heterogeneous morphology and suboptimal response to conventional therapies. Poly-L-lactic acid (PLLA), a biostimulatory agent, promotes neocollagenesis and has emerged as a promising therapeutic option. However, comparative data on different delivery modalities of PLLA and their effects on dermal remodeling and skin physiology remain limited. Objective: To compare two delivery modalities of PLLA (injectable versus mono-thread) and evaluate their effects on dermal remodeling, clinical outcomes, and safety in atrophic acne scars. Methods: This prospective split-face study included 24 patients with atrophic acne scars. The right facial side was treated with a single session of PLLA mono-threads, while the left side received two sessions of injectable PLLA at 6-week intervals. Clinical outcomes were assessed using Goodman and Baron's qualitative and quantitative grading systems over a 3-month follow-up period.
CONDITIONS
Official Title
Poly-L-Lactic Acid in Atrophic Acne Scars
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Both males and females
- Clinically diagnosed atrophic acne scars graded 2 to 4 by Goodman and Baron classification
You will not qualify if you...
- Active acne lesions
- Pregnancy or breastfeeding
- Bleeding disorders
- History of keloid scarring
- Systemic diseases that affect wound healing
- Acne scar treatment within the last 6 months
- Known allergy to components of Poly-L-lactic acid
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zagazig University Hospitals
Zagazig, Sharqia Province, Egypt, 2543
Actively Recruiting
Research Team
R
Reham Essam, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here