Actively Recruiting
Polygenic Risk Score for Optimizing Primary Prevention in Intermediate-Risk Populations
Led by University of Bern · Updated on 2025-07-25
204
Participants Needed
2
Research Sites
116 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine whether incorporating a polygenic risk score (PRS) can optimize primary cardiovascular disease prevention in individuals with intermediate cardiovascular risk. The main questions it aims to answer are: * Can a polygenic risk score improve risk stratification in intermediate-risk individuals? * Does disclosing polygenic risk information to patients and physicians lead to better preventive interventions (e.g., statin use, lifestyle changes)? Researchers will compare outcomes in participants with PRS disclosure versus standard risk assessment to see if PRS-guided prevention leads to improved cardiovascular risk management. Participants will: * Undergo baseline cardiovascular risk assessment * Provide a blood sample for PRS calculation * Complete follow-up visits for lifestyle counseling, medication review, and risk reassessment
CONDITIONS
Official Title
Polygenic Risk Score for Optimizing Primary Prevention in Intermediate-Risk Populations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 40 and 69 years
- Intermediate cardiovascular risk based on SCORE2 or SCORE2-Diabetes
- Able to understand German or French or have an interpreter
- Provided written informed consent
You will not qualify if you...
- Currently treated with lipid-lowering therapy such as statins, ezetimib, bempedoic acid, or PCSK-9 inhibitors
- History of cardiovascular disease including coronary artery disease, peripheral artery disease, or ischemic stroke
- Chronic kidney disease with eGFR below 30 ml/min or below 60 ml/min with albuminuria in diabetic patients with organ damage
- Participating in another cardiovascular risk or lifestyle intervention clinical trial
- Life expectancy less than one year
AI-Screening
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Trial Site Locations
Total: 2 locations
1
University of Bern, Institute of Primary Health Care (BIHAM)
Bern, Switzerland, 3012
Actively Recruiting
2
University of Lausanne, Centre Hospitalier Universitaire Vaudois (CHUV)
Lausanne, Switzerland
Not Yet Recruiting
Research Team
E
Elisavet Moutzouri, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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