Pilot Study of a Topical Cyanoacrylate Polymer Film for Treating Adults with Severe Palmar Hyperhidrosis

What this Trial Is About

Excessive sweating, known as hyperhidrosis, is a condition where the body produces more sweat than needed to regulate temperature. This affects daily life, causing stress and limiting social and professional activities, especially when it occurs on the palms. Primary palmar hyperhidrosis has few effective treatment options, with current choices often causing discomfort, side effects, or high costs, highlighting a need for better solutions. This pilot study aims to evaluate a topical cyanoacrylate TCA antiperspirant as a new treatment option for adults with palmar hyperhidrosis. Participants will apply a cyanoacrylate polymer topically to the palms once or twice daily for one week. This polymer forms a flexible film over sweat pores, potentially reducing sweating quickly without damaging skin or grip. The study is open-label and single-site, involving about 30 adults aged 18 and older. After baseline screening, participants will use the treatment daily and be monitored for safety and sweat reduction effects over a total of four weeks, including a follow-up phone call. During the study, researchers will assess sweating severity using the Hyperhidrosis Disease Severity Scale HDSS, measure sweat production, and test grip strength. Participants will complete daily sweat severity ratings, and safety will be monitored throughout. The main goal is to see if the treatment safely reduces sweating severity and improves hand function. The study concludes with a phone survey at four weeks to gather final data on treatment effects and participant experience.

A Polymer Film Device to Treat Excessive Palmar Sweating