Actively Recruiting
Polyphenol Metabotypes in People With Diabetes Type 2
Led by University Hospital, Ghent · Updated on 2026-03-23
100
Participants Needed
2
Research Sites
143 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Ghent
Lead Sponsor
U
University Ghent
Collaborating Sponsor
AI-Summary
What this Trial Is About
This cross-sectional study seeks to characterize the overall polyphenol metabotype in patients with T2DM in comparison to age-matched individuals without diabetes. Additionally, the study aims to identify factors that influence the polyphenol metabotype (transit time and gut microbial capacity to degrade polyphenols in particular).
CONDITIONS
Official Title
Polyphenol Metabotypes in People With Diabetes Type 2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged between 40 and 85 years
- Age-matched individuals without diabetes
- Body mass index (BMI) between 18.5 and 30
- No metabolic syndrome
- Persons diagnosed with type 2 diabetes mellitus (T2DM)
- Clinical diagnosis of T2DM for at least 2 years
- Stable medication use for at least 1 month
You will not qualify if you...
- Pregnancy or breastfeeding
- Acute use of anti/pre/probiotics in the last month
- Recent start of new drugs or dietary supplements
- Major changes in diet
- Major lifestyle changes
- Having gastrointestinal diseases such as inflammatory bowel disease
- Previous bariatric surgery
- Other forms of diabetes including cystic fibrosis-related diabetes, MODY, or type 1 diabetes
- Heart problems classified as NYHA 3 or 4 or previous cardiovascular events
- Liver problems including non-alcoholic steatohepatitis (NASH) and cirrhosis
- Lung problems such as COPD GOLD 3/4 or cystic fibrosis
- Uncontrolled thyroid function disruption in the past 6 months
- Use of coumarin derivatives or direct oral anticoagulant medication
- Receiving anti-cancer treatment like chemotherapy or immunotherapy
- Use of immunosuppressants (e.g., transplant medication)
- Use of antiepileptic drugs
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Ghent University
Ghent, East Flanders, Belgium, 9000
Not Yet Recruiting
2
Department of rehabilitation sciences - UGent
Ghent, Belgium
Actively Recruiting
Research Team
J
Jan Stautemas, PhD
CONTACT
P
Patrick Calders, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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