Actively Recruiting
Population-based Atrial Fibrillation Screening in Individuals With NT-proBNP Above Median in the Tromsø Study
Led by University Hospital of North Norway · Updated on 2026-01-15
4000
Participants Needed
2
Research Sites
487 weeks
Total Duration
On this page
Sponsors
U
University Hospital of North Norway
Lead Sponsor
U
UiT The Arctic University of Norway
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim is to investigate whether screening with long-term ECG monitoring in individuals with elevated NT-proBNP leads to a lower incidence of ischeamic stroke and death from vascular causes. The project is a sub-study within the 8th wave of the population based Tromsø Study. Information on previous diseases, medication use, and risk factors is collected through questionnaires, blood samples, and measurements of height, weight, blood pressure, and ECG. A total of 4,000 individuals with NT-proBNP levels above the median, without previously known atrial fibrillation (AF) or ongoing anticoagulation therapy, will be randomized to either long-term heart rhythm monitoring (7 days) or a control group without long-term ECG monitoring (2,000 in each group). Individuals with AF in the intervention group will be offered anticoagulation therapy in accordance with current guidelines. The intervention group and the control group will be compared with regards to incident stroke and death within a 6-year follow-up period. Information on endpoints and anticoagulation use will be obtained through linkage to national registries.
CONDITIONS
Official Title
Population-based Atrial Fibrillation Screening in Individuals With NT-proBNP Above Median in the Tromsø Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 40 years or older
- NT-proBNP above the median level
- Informed consent for participation
You will not qualify if you...
- History of atrial fibrillation (self-reported)
- Current use of anticoagulation therapy
- Presence of pacemaker or cardiac resynchronization therapy (CRT) device
- No available smartphone
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Uit The Arctic University of Norway
Tromsø, Norway, 1902
Actively Recruiting
2
University Hospital of North Norway Health Trust
Tromsø, Norway
Actively Recruiting
Research Team
A
Agnethe Eltoft, MD, PhD
CONTACT
E
Emelia Gjesvik
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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