Actively Recruiting
Population Pharmacokinetics of Anti-infectives in Hospitalized Patients
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-11-20
60
Participants Needed
1
Research Sites
626 weeks
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
U
URC-CIC Paris Descartes Necker Cochin
Collaborating Sponsor
AI-Summary
What this Trial Is About
In case of sepsis, the therapeutic success is strongly influenced by the choice of anti-infectives (AI) in terms of spectrum, dosage and administration schedule. It is therefore critical to achieve adequate AI concentration as quickly as possible. This protocol aims to define a common framework to studies conducted jointly by the Antimicrobial Stewardship Tea, the Pharmacology department of Cochin hospital and within the APHP Centre hospital group for various AI in a range of specific study populations (intensive care unit patients, neutropenic patients…). These studies will use mathematical modeling methodologies to investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of different AI including PK/PD targets or any other biological compartment. The effects of covariates on PK and PD parameters will be investigated to better explain the between-subject variability (BSV) and to ultimately suggest individualized dosage regimens.
CONDITIONS
Official Title
Population Pharmacokinetics of Anti-infectives in Hospitalized Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults hospitalized at Cochin hospital receiving an anti-infective drug
- Patients requiring at least one anti-infective drug concentration measurement or other biological compartment analysis at Cochin pharmacology department
You will not qualify if you...
- Patients who have refused the recovery and analysis of their data
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cochin Hospital
Paris, Paris, France, 75014
Actively Recruiting
Research Team
E
Etienne CANOUI, MD
CONTACT
L
Laure CHOUPEAUX, Master
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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