Actively Recruiting
Portable VR-based Chromatic Pupilloperimeter for Diagnosis and Monitoring of Traumatic Brain Injury
Led by Sheba Medical Center · Updated on 2026-04-02
150
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
Sponsors
S
Sheba Medical Center
Lead Sponsor
R
Reichman University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Accurate and non-invasive methods for objectively identifying and monitoring head injuries (such as a concussion) are still an unmet need. It is known that pupil constriction in response to light stimuli can reflect changes in neural activity in the brain and is associated with sleep disturbances. The investigators aim to examine the feasibility of using virtual reality goggles for monitoring traumatic brain injury by analyzing the pupillary response to multifocal chromatic stimuli. The VR device was programmed to present brief, low-intensity light stimuli (without glare), while the headset's camera records the pupil's reaction.
CONDITIONS
Official Title
Portable VR-based Chromatic Pupilloperimeter for Diagnosis and Monitoring of Traumatic Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female subjects
- Clear ocular media
- For TBI group: combat-related mild to moderate TBI
- For TBI group: elevated blood biomarkers (Abbott Allinity I, GFAP/UCHL1) and/or positive initial trauma head CT for acute intracranial trauma
- For Non-TBI Trauma group: age- and gender-similar soldiers without TBI who screen negative based on symptoms, blood, and/or head CT
You will not qualify if you...
- Neuropsychiatric diseases
- Any other neurodegenerative diseases
- History of stroke, epilepsy, head trauma, or head tumors
- Ocular disease or ocular surgery within the last six months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sheba Medical Center
Tel Litwinsky, Tel Aviv (Gosh Dan), Israel, 608552621
Actively Recruiting
Research Team
L
Lori Gueta
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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