Study of Positive Psychology Program PATH to Improve Mental Health and Quality of Life in Adults After Hematopoietic Stem Cell Transplant

What this Trial Is About

Researchers are studying the effects of a positive psychology program called PATH on anxiety, depression, and quality of life among adults who have survived hematopoietic stem cell transplantation HSCT. The study focuses on the recovery phase starting around 100 days after HSCT, a time when patients may experience both physical and psychological challenges. This multi-site randomized trial aims to compare the PATH intervention with usual care to see if it helps improve mental health and well-being using validated tools. The PATH intervention is delivered remotely by phone and includes three modules lasting three weeks each. These modules focus on gratitude, personal strengths, meaning, goal-setting, and daily physical activity, with weekly 30-minute guided sessions led by a trained interventionist. Participants are randomized to either receive PATH or continue with their usual care and support from their HSCT teams. Both groups complete questionnaires at scheduled times throughout the study. Participants will be involved in completing questionnaires in person, online, by phone, or mail at several points up to 40 weeks. The main outcome measured is anxiety at 10 weeks using a standardized scale, with other outcomes including depression symptoms, gratitude, positive affect, physical function, and quality of life monitored over time. The study includes safety and adherence monitoring to assess the impact of the intervention during recovery. Participation lasts for several months with assessments planned to capture changes over this period.

Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors