Evaluating MRI-Guided Laser Interstitial Thermal Therapy for Treating Medically Resistant Tremors in Parkinsons Disease and Essential Tremor Patients

What this Trial Is About

Researchers are investigating the use of MRI-Guided Laser Interstitial Thermal Therapy MRIg-LITT to treat medically intractable tremors caused by Parkinsons disease or essential tremor. This study focuses on patients who cannot undergo deep brain stimulation due to medical, diagnostic, or social reasons, or who refuse that treatment. MRIg-LITT is a minimally invasive surgical method previously shown to be effective and safe for epilepsy and brain tumors, but its use for tremor treatment has not yet been studied. The study involves implanting a laser electrode surgically into the ventral and intermediary nucleus of the thalamus VIM to perform unilateral thalamotomy using MRIg-LITT. This procedure aims to reduce tremors in patients resistant to medical therapy. The trial is an interventional study without masking or placebo, focusing on patients 18 years or older with Parkinsons or essential tremor who have contraindications to or refuse deep brain stimulation. Participants will be monitored for changes in total body weight and cumulative fluid balance 72 hours after the procedure. The study will assess the safety and effects of the MRIg-LITT thalamotomy treatment. Researchers will carefully evaluate any adverse events and overall treatment outcomes during this period. The trial is sponsored by Centre Hospitalier Universitaire, Amiens, and is expected to continue until April 2026.

Possibilities of Use MRI-Guided Laser Interstitial Thermal Therapy in Medically Intractable Tremor