Actively Recruiting
Possibilities of Use MRI-Guided Laser Interstitial Thermal Therapy in Medically Intractable Tremor
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2025-01-29
15
Participants Needed
1
Research Sites
86 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire, Amiens
Lead Sponsor
U
University Hospital, Rouen
Collaborating Sponsor
AI-Summary
What this Trial Is About
Medically intractable tremors are a common difficult clinical situation. Deep brain stimulation decreases Parkinson's disease tremor and essential tremor, but not all patients are candidates from a diagnostic, medical, or social standpoint, prompting the need for alternative surgical strategies. Less invasive lesional brain surgery (thalamotomy) procedures by radio-surgery or MRI-guided focused ultrasound have emerged and have proven to be effective in these third-line indications. Recently, a new technology has emerged allowing the performance of minimally invasive lesion surgeries by MRI-Guided Laser Interstitial Thermal Therapy (MRIg-LITT). MRIg-LITT has been shown to be effective and safe in management of epilepsies and brain tumors. However, no study has evaluated MRIg-LITT for performing thalamotomy in medically intractable tremor.In a pilot study, the investigators propose to evaluate the effect and safety of unilateral thalamotomy by MRIg-LITT in the management of medically intractable tremor of parkinsonian or essential origin.
CONDITIONS
Official Title
Possibilities of Use MRI-Guided Laser Interstitial Thermal Therapy in Medically Intractable Tremor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years age or older with Parkinson's disease or essential tremor
- Tremor resistant to medical therapy
- Contraindication to deep brain stimulation or refusal of deep brain stimulation
You will not qualify if you...
- Contraindication to MRI
- Contraindication to general anesthesia
- Unable to give free and informed consent due to cognitive or psychiatric disorders
- Brain anatomical abnormalities preventing intervention
- Adults under guardianship, curatorship, or deprived of liberty
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHRU Amiens
Salouël, France, 80480
Actively Recruiting
Research Team
M
Michel LEFRANC, Pr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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