Actively Recruiting
Possible Efficacy and Safety of Mebendazole in Patients With Ulcerative Colitis Treated With Mesalamine
Led by Tanta University · Updated on 2026-02-06
46
Participants Needed
1
Research Sites
105 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To evaluate the possible efficacy and safety of mebendazole in patients with ulcerative colitis treated with mesalamine
CONDITIONS
Official Title
Possible Efficacy and Safety of Mebendazole in Patients With Ulcerative Colitis Treated With Mesalamine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Both male and female patients are included
- Mild and moderate ulcerative colitis diagnosed and confirmed by endoscopy
- Patient treated with 5-aminosalicylic acid (mesalamine)
You will not qualify if you...
- Patients with severe ulcerative colitis
- Significant liver and kidney function abnormalities
- Diabetic patients
- Patients with colorectal cancer
- Patients taking rectal or systemic steroids
- Patients on immunosuppressants or biological therapies
- Addiction to alcohol and/or drugs
- Known allergy to the studied medications
- History of complete or partial colectomy
- Patients with congestive heart failure or other heart diseases (arrhythmia, ischemic heart disease including angina and myocardial infarction)
- Patients with other inflammatory diseases and active infection
- Patients with stressful conditions (COPD, morbid obesity)
- Patients with liver disease
- Patients with thrombocytopenia and neutropenia
- Patients with any type of seizures
- Patients with renal disease
- Patients with coagulation disorders
- Patients on metronidazole
- Patients with hypersensitivity to mebendazole, albendazole, or benzimidazole
- Patients using antioxidants
- Pregnant and lactating females
- Patients receiving metronidazole, warfarin, low dose aspirin, clopidogrel, enzyme inducers (phenytoin, carbamazepine) or inhibitors (valproate) to avoid drug interactions
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Tanta Unuversity
Tanta, Egypt, 34518
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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