Actively Recruiting
Post-CA Neuroprotection With Magnesium
Led by NYU Langone Health · Updated on 2026-04-07
178
Participants Needed
1
Research Sites
66 weeks
Total Duration
On this page
Sponsors
N
NYU Langone Health
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this pilot interventional study is to collect preliminary data on administering magnesium sulfate as a neuroprotective medication in patients who achieved Return of Spontaneous Circulation (ROSC) following Cardiac Arrest (CA). The primary aims are to assess the feasibility and safety of administering magnesium and measure serum markers of neuronal injury at prespecified time points in the post-cardiac arrest period. Because this is a pilot study with a limited sample size, the primary objective is to evaluate the precision and stability of the collected measures to inform the design and formal analysis in a larger trial.
CONDITIONS
Official Title
Post-CA Neuroprotection With Magnesium
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Documented post-cardiac arrest patient with Return of Spontaneous Circulation (ROSC) achieved less than 2 hours before recruitment
You will not qualify if you...
- Age younger than 18 years or older than 85 years
- Traumatic cardiac arrests
- Unsustained ROSC (less than 20 minutes)
- Patient responsive or able to follow motor commands within 1 hour of ROSC
- Plan to withdraw life support within 72 hours of ROSC
- Known pregnant women at the time of cardiac arrest
- Known prisoners at the time of cardiac arrest
- Medical or social conditions deemed inappropriate for the study by the principal investigator or clinical team
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
Research Team
A
Anelly Gonzales
CONTACT
N
Natalia Leontovich
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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