Actively Recruiting
Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Led by Thomas Jefferson University · Updated on 2025-09-03
825
Participants Needed
1
Research Sites
118 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks. Multimodal non-opioid pain medications, including acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are the preferred first-line therapies. There is no standard practice, however, on best dosing schedules (ie staggered or different time v. simultaneous or same time). This protocol describes a randomized clinical trial aimed to determine whether staggered dosing of acetaminophen and NSAIDs in superior to simultaneous dosing in controlling post-cesarean pain.
CONDITIONS
Official Title
Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 34 weeks gestation
- Singleton pregnancy
- Delivery planned by cesarean section under regional anesthesia
You will not qualify if you...
- Allergy or contraindication to acetaminophen or NSAIDs
- Current or past opioid use or misuse
- Intrauterine fetal demise
- Major congenital anomaly
- Use of general anesthesia during or planned for cesarean
- Mid-line vertical skin incision
- Use of intraoperative local analgesia such as Transversus Abdominis Plane (TAP) block or wound infiltration
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
Research Team
W
Whitney Bender, MD
CONTACT
B
Brandy Firman
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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