Study of Neuromuscular Function and Risk of Musculoskeletal Injury After Concussion
in Military Service Members and Active Civilians Aged 18 to 40
Led by Walter Reed National Military Medical Center · Updated on 2026-01-27
148
Participants Needed
3
Research Sites
52 weeks
Total Duration
AI-Summary
What this Trial Is About
Musculoskeletal injuries MSKI and traumatic brain injury TBI, especially concussions, are common and serious issues affecting military Service Members and physically active civilians. This research aims to identify how neuromuscular control changes after concussion may increase the risk of MSKI. The study will compare individuals who have had a concussion with those who have not, to understand the reasons behind this increased injury risk and help develop targeted prevention strategies.
Participants will undergo detailed assessments including dynamic movement tests like jump-landing, single leg hop, anticipated cut, and gait tasks, along with strength and muscle activation tests. Sensory evaluations will assess proprioception and light touch sensation. These assessments occur at three time points within 5 days of becoming asymptomatic post-concussion, then at 6 and 12 weeks after the initial assessment. Both concussed and matched non-concussed participants will complete the same testing and self-report psychosocial measures.
During the study, participants will report any new musculoskeletal injuries and complete monthly questionnaires for about one year. Researchers will track changes in movement, muscle function, sensory abilities, and patient-reported outcomes over time. The study also monitors psychological factors such as anxiety, depression, and pain interference. This comprehensive approach will help measure how neuromuscular control evolves after concussion and its connection to injury risk.
CONDITIONS
Brief Title
Post-Concussion Musculoskeletal Injury Risks
Research Team
B
Bradford D Hendershot, PhD
J
Joseph G Wasser, PhD
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For concussed group: self-reported asymptomatic after concussion and diagnosed within 5 days prior to enrollment.
Access to a functional email address and internet for completing questionnaires.
For non-concussed group: active duty Service Members or physically active civilians with no concussion in past 5 years.
Matched to concussed participants by gender, age (within 2 years), height, weight, body mass index (within 5%), and physical activity type and duration.
You will not qualify if you...
Unable to read or understand English.
Hospitalized following concussion.
Concussion not caused by physical activity (e.g., blast injury, fall, motor vehicle accident).
Loss of consciousness longer than 30 minutes.
Altered consciousness longer than 24 hours.
Post-traumatic amnesia lasting more than 1 day.
Glasgow Coma Scale score below 13.
Abnormal brain imaging findings.
Took longer than 21 days to become asymptomatic after concussion.
Musculoskeletal injury in last 6 months causing missed or altered physical activity for 3 or more days.
History of musculoskeletal injury surgery.
Pregnant females (eligible after medical clearance post-pregnancy).
Contraindications for electrical stimulation including active deep vein thrombosis, infections, malignancy, skin disease, or implanted electronic devices or materials.
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Neuromuscular and Biomechanical Assessments
Duration - Initial visit plus follow-up assessments at 6 weeks and 12 weeks post-initial assessment (±72 hours)
Participants complete comprehensive neuromuscular, biomechanical, sensory, and psychosocial assessments to evaluate neuromuscular control and musculoskeletal injury risk following concussion.
3 visits (in-person) at initial, 6 weeks, and 12 weeks
Monthly Self-Reported Outcome Monitoring
Duration - Up to 1 year
Participants self-report musculoskeletal injuries and complete psychosocial questionnaires monthly to monitor changes over approximately one year following the initial assessment.
Monthly remote assessments via email or internet
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Investigating post-mild traumatic brain injury neuromuscular function and musculoskeletal injury risk: A protocol for a prospective, observational, case-controlled study in service members and active individuals.
Robert C Lynall, Joseph G Wasser, Daniel I Brooks...