Actively Recruiting
Post-discharge Malaria Chemoprevention Implementation Trial in Benin
Led by Institut de Recherche Clinique du Benin · Updated on 2025-07-24
648
Participants Needed
2
Research Sites
78 weeks
Total Duration
On this page
Sponsors
I
Institut de Recherche Clinique du Benin
Lead Sponsor
L
Liverpool School of Tropical Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
The proposed research aims to conduct implementation trials in Benin, co-designed with national stakeholders, to evaluate different delivery strategies for optimizing health system delivery of post-discharge malaria chemoprevention (PDMC) drugs and adherence to PDMC. This chemoprevention strategy is effective in reducing hospital readmissions and deaths after discharge. However, there is no clear delivery platform for PDMC, and adherence to the 3-day dosing regimen, provided monthly three times after discharge, is a potential limitation. The current trial will provide evidence-based data on acceptability, feasibility, and cost-effectiveness to aid decision-makers. The evidence generated will be used to support the effective implementation and scale-up of PDMC in high malaria-endemic areas such as Benin.
CONDITIONS
Official Title
Post-discharge Malaria Chemoprevention Implementation Trial in Benin
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged below 10 years of both sexes
- Hospitalised with severe anaemia or severe malaria defined by haemoglobin below 5.0 g/dl or PCV below 15%, or requirement for blood transfusion, or confirmed malaria infection requiring parenteral artesunate
- Clinically stable and able to take oral medication
- Post-transfusion haemoglobin below 5 g/dL
You will not qualify if you...
- Recognised specific other causes of severe anaemia such as trauma, haematological malignancy, or known bleeding disorders like haemophilia
- Sickle cell anaemia or sickle cell disease
- Body weight below 5 kg
- Non-resident in the study area
- Previous participation in the study
- Need for prohibited medication or scheduled surgery during the 6-month study period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Goho Departmental Hospital Centre
Abomey, Benin
Not Yet Recruiting
2
Centre Hospitalier Universitaire de la Mere et de l'Enfant Lagune (CHU-MEL)
Cotonou, Benin
Actively Recruiting
Research Team
M
Manfred Accrombessi, MD, PhD
CONTACT
A
Achille Massougbodji, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here