Actively Recruiting
Evaluation of Post Extraction Hard Tissue Alteration Following Ridge Preservation In The Esthetic Zone Using Partially Demineralized Autogenous Dentine Graft Versus Xenograft: A Randomized Controlled Clinical Trial.
Led by Cairo University · Updated on 2024-08-14
23
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the differences between using a partially demineralized autogenous dentin graft and a xenograft in bone regeneration after tooth extraction in the esthetic zone. The study focuses on clinical, radiographic, and histomorphometric outcomes related to alveolar ridge preservation in patients requiring extraction of non-restorable teeth. This research aims to compare the effects of these two graft materials on hard tissue changes following extraction and ridge preservation procedures. Participants will undergo initial periodontal therapy including cleaning and polishing, followed by atraumatic tooth extraction. The sockets will be filled with either the autogenous dentin graft prepared by a specialized device or a bovine xenograft, both covered with a collagen membrane secured by sutures. The study includes a test group receiving the dentin graft and a control group receiving the xenograft. After six months, bone biopsies and implant placements will be performed to evaluate the healing and regenerative outcomes. Participants will be assessed before surgery, immediately after, and six months post-surgery using clinical parameters and cone-beam CT scans to measure horizontal ridge width and ridge height changes. Histological analysis will determine new bone formation and residual graft presence. Implant primary stability will also be evaluated. Postoperative care includes antibiotics, pain management, oral hygiene instructions, and suture removal after two weeks. The total follow-up period for each participant is six months.
CONDITIONS
Brief Title
Post Extraction Alterations Following Ridge Preservation In The Esthetic Zone Using Partially Demineralized Autogenous Dentine Graft Versus Xenograft
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with non-restorable teeth and Type II extraction socket in the esthetic zone indicated for extraction due to periodontal, carious, or traumatic reasons.
- Healthy patients with adequate oral hygiene (bleeding on probing 60%; Plaque index 60%).
- Adults 18 years old and above.
- Patients willing to accept a 6-month follow-up period and provide informed consent.
You will not qualify if you...
- Heavy smokers (more than 10 cigarettes per day or using e-cigarettes with nicotine dose >6 mg/ml).
- Patients with systemic conditions that may affect healing or bone metabolism (e.g., diabetes).
- Patients with poor oral hygiene (bleeding on probing >20%; Plaque index >20%).
- Presence of acute periapical infection.
- Presence of severe periodontal destruction.
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day procedure with 2 weeks of postoperative care
Participants undergo atraumatic tooth extraction followed by alveolar ridge preservation using either an autogenous partially demineralized dentin graft or a xenograft. This includes socket cleaning, graft placement, collagen membrane coverage, and suturing.
1 surgery visit and suture removal visit after 2 weeks
Duration - 6 months
Participants receive postoperative care instructions, prescribed medications, and are monitored with CBCT scans on the first day after surgery and at 6 months. At 6 months, a bone biopsy and implant placement are performed under local anesthesia.
1 baseline CBCT visit, 1 suture removal visit, 1 final CBCT visit, and 1 implant placement visit
Trial Site Locations
Total: 1 location
1
Faculty of Dentistry Cairo University
Cairo, Egypt
Actively Recruiting
Research Team
R
Riham A Alshikh Hani Alkurdee, Bachelor
W
Weam El-Battawy, Ass. Prof.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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