Actively Recruiting
Evaluation of Post Extraction Hard Tissue Changes Following Ridge Preservation in the Esthetic Zone Using Allogeneic Dentin Matrix Versus Autogenous Partially Demineralized Dentine Matrix
Led by Cairo University · Updated on 2024-08-06
32
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how well two types of dentin matrix grafts help preserve the bone after tooth extraction in the smile area, called the aesthetic zone. The study compares an allogenic dentin matrix, which is processed from donor teeth, with an autogenous partially demineralized dentin matrix (APDDM), made from the patient's own extracted tooth. The goal is to see which method better reduces hard tissue changes and supports bone healing. This clinical trial is randomized and controlled to provide reliable comparisons. The allogenic dentin matrix undergoes a detailed cleaning and processing procedure including washing, ultrasonic cleaning, defatting, demineralization, dehydration, freeze-drying, and sterilization before being placed in the extraction socket. The autogenous dentin is cleaned, ground using a special device, partially demineralized, and then packed into the socket. Both groups have the graft covered with a collagen membrane that is secured with sutures. After six months of healing, a biopsy sample will be collected during implant placement to evaluate the bone formation. Participants will visit the clinic for periodontal and radiographic exams before treatment. After tooth extraction and graft placement, they will be monitored over a six-month period, including radiographic imaging to measure bone changes and bone width loss. Researchers will also assess vital new bone formation, the presence of residual graft material, and the stability of dental implants placed later. This study involves outpatient visits and tissue sampling to fully understand the healing outcomes.
CONDITIONS
Brief Title
Post Extraction Changes Following Ridge Preservation Using Allogenis Dentin Vs Autogenous Partially Demineralized Dentin
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with good health status (ASA-1, ASA-2).
- Adults aged 18 to 60 years.
- Patients with non-restorable teeth in the aesthetic zone due to periodontal, carious, or traumatic reasons.
- Extraction socket with no more than 50% buccal bone loss.
- Patients willing to accept a 6-month follow-up period.
- Patients who provide informed consent.
You will not qualify if you...
- Patients with systemic conditions that may impair healing, such as uncontrolled diabetes.
- Patients with poor oral hygiene.
- Pregnant patients.
- Smokers.
- Patients taking medications that could compromise healing.
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Not specified
Participants receive periodontal treatment including scaling, debridement, restoration adjustment, and mechanical plaque control instructions.
1 visit (in-person)
Duration - Day of surgery
Participants undergo atraumatic tooth extraction followed by alveolar ridge preservation using either allogeneic dentin matrix or autogenous partially demineralized dentin matrix graft covered with a collagen membrane.
1 surgical visit (in-person)
Duration - 6 months
Participants undergo a healing period of 6 months after ridge preservation before implant placement.
Follow-up visits as needed (not specified)
Duration - 1 day (surgical visit)
Participants receive implant placement surgery after complete bone healing of the extraction socket.
1 surgical visit (in-person)
Duration - 6 months post-surgery
Participants are monitored for implant stability and bone changes with radiographic and histological assessments up to 6 months after surgery.
1 follow-up visit at 6 months post-implant placement
Trial Site Locations
Total: 1 location
1
Cairo University
Cairo, Cairo, Elmanil, Egypt, 4240101, Egypt
Actively Recruiting
Research Team
A
Abdullah Matar
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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