Actively Recruiting

Phase Not Applicable
Age: 18Years - 60Years
All Genders
Healthy Volunteers
ID06477887

Evaluation of Post Extraction Hard Tissue Changes Following Ridge Preservation in the Esthetic Zone Using Allogeneic Dentin Matrix Versus Autogenous Partially Demineralized Dentine Matrix

Led by Cairo University · Updated on 2024-08-06

32

Participants Needed

1

Research Sites

17 weeks

Total Duration

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AI-Summary

What this Trial Is About

Researchers are studying how well two types of dentin matrix grafts help preserve the bone after tooth extraction in the smile area, called the aesthetic zone. The study compares an allogenic dentin matrix, which is processed from donor teeth, with an autogenous partially demineralized dentin matrix (APDDM), made from the patient's own extracted tooth. The goal is to see which method better reduces hard tissue changes and supports bone healing. This clinical trial is randomized and controlled to provide reliable comparisons. The allogenic dentin matrix undergoes a detailed cleaning and processing procedure including washing, ultrasonic cleaning, defatting, demineralization, dehydration, freeze-drying, and sterilization before being placed in the extraction socket. The autogenous dentin is cleaned, ground using a special device, partially demineralized, and then packed into the socket. Both groups have the graft covered with a collagen membrane that is secured with sutures. After six months of healing, a biopsy sample will be collected during implant placement to evaluate the bone formation. Participants will visit the clinic for periodontal and radiographic exams before treatment. After tooth extraction and graft placement, they will be monitored over a six-month period, including radiographic imaging to measure bone changes and bone width loss. Researchers will also assess vital new bone formation, the presence of residual graft material, and the stability of dental implants placed later. This study involves outpatient visits and tissue sampling to fully understand the healing outcomes.

CONDITIONS

Brief Title

Post Extraction Changes Following Ridge Preservation Using Allogenis Dentin Vs Autogenous Partially Demineralized Dentin

Who Can Participate

Age: 18Years - 60Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients with good health status (ASA-1, ASA-2).
  • Adults aged 18 to 60 years.
  • Patients with non-restorable teeth in the aesthetic zone due to periodontal, carious, or traumatic reasons.
  • Extraction socket with no more than 50% buccal bone loss.
  • Patients willing to accept a 6-month follow-up period.
  • Patients who provide informed consent.
Not Eligible

You will not qualify if you...

  • Patients with systemic conditions that may impair healing, such as uncontrolled diabetes.
  • Patients with poor oral hygiene.
  • Pregnant patients.
  • Smokers.
  • Patients taking medications that could compromise healing.

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Initial Therapy

Duration - Not specified

Participants receive periodontal treatment including scaling, debridement, restoration adjustment, and mechanical plaque control instructions.

1 visit (in-person)

Tooth Extraction and Ridge Preservation

Duration - Day of surgery

Participants undergo atraumatic tooth extraction followed by alveolar ridge preservation using either allogeneic dentin matrix or autogenous partially demineralized dentin matrix graft covered with a collagen membrane.

1 surgical visit (in-person)

Healing Period

Duration - 6 months

Participants undergo a healing period of 6 months after ridge preservation before implant placement.

Follow-up visits as needed (not specified)

Late Implant Placement

Duration - 1 day (surgical visit)

Participants receive implant placement surgery after complete bone healing of the extraction socket.

1 surgical visit (in-person)

Post-Implant Follow-up

Duration - 6 months post-surgery

Participants are monitored for implant stability and bone changes with radiographic and histological assessments up to 6 months after surgery.

1 follow-up visit at 6 months post-implant placement

Trial Site Locations

Total: 1 location

1

Cairo University

Cairo, Cairo, Elmanil, Egypt, 4240101, Egypt

Actively Recruiting

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Research Team

A

Abdullah Matar

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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