Validation of a Post-Filter Hematocrit Calculation Formula Compared to Measured Values in Continuous Renal Replacement Therapy Patients

What this Trial Is About

Researchers are evaluating a new formula to calculate post-filter hematocrit in patients undergoing continuous renal replacement therapy (CRRT). This study aims to validate whether the calculated post-filter hematocrit matches the values measured directly from blood samples. Filter clotting is a significant complication during CRRT, causing blood loss and treatment challenges, so finding accurate markers to predict clotting risk is important. Participants will have blood samples collected from their CRRT machine's post-filter lines at various times and flow rates. The study compares the hematocrit calculated by the formula HCTpost=HCTpre/(FF(HCTpre-1)+1) to measured hematocrit values from these samples. All participants receive the same procedure of both calculation and measurement. The study is cross-sectional, with participation lasting generally no longer than one day. During the study, four post-filter blood samples are collected over about 40 minutes. Researchers will analyze agreement between measured and calculated hematocrit and explore how CRRT settings and patient factors affect differences. There are no additional treatments or follow-up visits. Participation ends after the final blood draw, and safety monitoring is not specifically mentioned due to the short, observational nature of the procedure.

Post-Filter Hematocrit