Application of a Novel Antimicrobial Wash Versus Hydrogen Peroxide Versus Povidone-iodine to the Skin During Shoulder Replacement Surgery to Study Cutibacterium Acnes Infection Rates

What this Trial Is About

This trial studies adults undergoing primary shoulder replacement surgery to compare the effects of different post-incision antimicrobial washes on the presence of Cutibacterium acnes (C. Acnes) bacteria. The goal is to find out whether applying these solutions after the initial incision can reduce positive C. Acnes cultures, which are linked to infections. Participants are adults with shoulder conditions like severe osteoarthritis or rotator cuff arthropathy who have not improved after conservative treatment. Participants are randomly assigned to one of four groups: Xperience Antimicrobial Wash, 3% hydrogen peroxide, 10% povidone-iodine (betadine), or no post-incision treatment (control). Each antimicrobial is applied along the entire dermis with a soaked surgical sponge right after the initial incision. The control group does not receive any dermal treatment before bacterial cultures are collected. During the study, cultures are taken from the surgical site before and after incision, the shoulder joint, and the operating room air. These cultures are monitored daily up to 18 days after surgery for C. Acnes. Patients have follow-up visits at 2 weeks, 6 weeks, 3 months, 6 months, and 1 year to assess wound healing and complications. Data from medical records and clinical evaluations are collected and analyzed to understand the treatment effects and any surgical complications.

Post-incision Antimicrobial Wash vs C. Acnes in Shoulder Arthroplasty