Actively Recruiting
Post-line Treatment With Teniposide for c-Myc-driven Extensive-stage Small Cell Lung Cancer
Led by Shanghai Pulmonary Hospital, Shanghai, China · Updated on 2025-12-05
15
Participants Needed
1
Research Sites
98 weeks
Total Duration
On this page
Sponsors
S
Shanghai Pulmonary Hospital, Shanghai, China
Lead Sponsor
C
CHINA RESOURCES DOUBLE-CRANE PHARMACEUTICAL CO.,LTD
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study is being conducted to investigate the efficacy and safety of teniposide in patients with extensive-stage small cell lung cancer who have failed standard treatment and with high expression of the c-Myc-driven FBXW2/MYC gene. Based on the results, the study will explore the correlation between the expression of FBXW2/MYC and the efficacy of teniposide.
CONDITIONS
Official Title
Post-line Treatment With Teniposide for c-Myc-driven Extensive-stage Small Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of extensive-stage small cell lung cancer
- Disease progression after at least one prior chemotherapy treatment
- ECOG performance status score of 0 to 1
- Presence of c-Myc-driven disease
- Expected survival of 3 months or more
- Age between 18 and 75 years old
- Signed informed consent following ICH-GCP guidelines
You will not qualify if you...
- No measurable cancer lesions
- Presence of other severe or persistent diseases or organ dysfunction
- Women planning pregnancy or men planning family planning
- Women who are pregnant or breastfeeding
- Inability to follow the study protocol as directed by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Pulmonary Hospital, Shanghai, China
Shanghai, Shanghai Municipality, China, 200331
Actively Recruiting
Research Team
J
jiale Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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