Actively Recruiting
Post-Op Pain Control for Prophylactic Intramedullary Nailing.
Led by St. Louis University · Updated on 2026-04-22
60
Participants Needed
1
Research Sites
423 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Nationally, the opioid crisis has become a major epidemic with increasing mortality rates each year. Orthopedic surgeons routinely prescribe narcotics instead of NSAIDs for post-op pain control because of risk of delayed healing and nonunion due to NSAID use. Orthopedic oncology, however, has a unique subset of patients that undergo prophylactic placement of intramedullary femoral nails. Because no fracture is present, these patients do not rely on inflammatory healing factors, allowing for post-op NSAID use. This study sets out to determine the effect of post-op toradol use in addition to opioids compared to solely opioids in patients undergoing prophylactic nailing of the femur.
CONDITIONS
Official Title
Post-Op Pain Control for Prophylactic Intramedullary Nailing.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Femoral shaft or neck bone lesion
- 18 years old or greater
- Planned prophylactic intramedullary nailing of one femur
You will not qualify if you...
- Concurrent pathologic fracture
- Advanced renal impairment (eGFR <30 mL/min)
- History of peptic ulcer disease with bleeding or hospitalization
- Allergy to NSAIDs or aspirin
- Chemotherapy preventing NSAID use
- Liver disease that prevents ketorolac use
- Heart failure or cardiovascular disease preventing ketorolac use
- Pregnancy
- Allergy to narcotics causing anaphylaxis
- Coagulation disorders or need for anticoagulant/antiplatelet therapy during treatment
- Allergy to acetaminophen causing anaphylaxis
- Current use of probenecid
- Current use of pentoxifylline
- History of aspirin-induced asthma
- Known opioid dependence, abuse, or addiction
- Bilateral intramedullary nailing of the femurs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Saint Louis University
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
D
David Greenberg, MD
CONTACT
A
Allison Gruender, MSN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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