Post-Operative Cognitive Dysfunction After Breast Surgery: Incidence and Relation With Common Intraoperative Neuromonitoring Data and Concentration of Propofol and Remifentanil Infused With Targeted Controlled Infusion (TCI) in Women With Laryngeal Mask Airway

What this Trial Is About

This research investigates Post-Operative Cognitive Dysfunction (POCD) and Postoperative Delirium in women undergoing breast surgery under general anesthesia. It aims to understand whether changes in neurocognitive test results before and after surgery relate to drug concentrations and common monitoring values during surgery. The study focuses on anesthesia delivered with targeted-controlled infusion of propofol and remifentanil and uses a laryngeal mask airway for airway management. Participants receive general anesthesia using propofol and remifentanil administered via targeted-controlled infusion, with the airway managed by a laryngeal mask. Researchers will monitor common intraoperative neuromonitoring values such as Bispectral Index, Entropy monitoring, and Surgical Plethysmographic Index, along with pupillometry measures including pupil diameter, latency, and maximum contraction velocity. The study observes neurocognitive functions and delirium occurrences linked to these anesthesia and monitoring parameters. Women enrolled will undergo several cognitive assessments before surgery and after awakening. These include the Montreal Cognitive Assessment, Trail Making Tests A and B, Digit Span Test, Confusion Assessment Method, Short Portable Mental Status Questionnaire, Mini-Mental State Evaluation, and the 4AT test. Evaluations occur one day before and within an hour to one day after surgery. The study tracks the incidence of cognitive dysfunction and delirium, aiming to correlate these outcomes with anesthesia drug levels and monitoring data over the study duration ending in 2027.

Post Operative Cognitive Dysfunction After Breast Surgery