Actively Recruiting
Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial
Led by Emory University · Updated on 2026-02-10
200
Participants Needed
1
Research Sites
185 weeks
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This phase II trial tests the effect of decreasing (tapering) doses of dexamethasone on steroid side effects in patients after surgery to remove (craniotomy) a brain tumor. Steroids are the gold standard post-surgery treatment to reduce swelling (edema) at the surgical site to reduce neurological symptoms. Although, corticosteroids reduce edema, they have side effects including high blood sugar, high blood pressure, and can impair wound healing. Dexamethasone is in a class of medications called corticosteroids. It is used to reduce inflammation and lower the body's immune response. It also works to treat other conditions by reducing swelling and redness. Tapering doses dexamethasone may decrease steroid side effects without increasing the risk of edema in patients with brain tumors after a craniotomy.
CONDITIONS
Official Title
Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with radiographic findings consistent with high grade glioma, low grade glioma, meningioma, or brain metastasis
- Age 18 years or older
You will not qualify if you...
- Known hypothalamic-pituitary-adrenal (HPA) axis dysfunction
- Tumor causing compression of the sella or pituitary dysfunction
- Known immunodeficiency including severe combined immunodeficiency, common variable immunodeficiency, or lymphocytopenia
- Taking immunosuppressive drugs such as methotrexate, mycophenolate, rapamycin, tacrolimus, adalimumab, infliximab
- More than two weeks of recent daily corticosteroid use or corticosteroids equivalent to over 85 mg dexamethasone in the last month
- Current lymphoma or leukemia
- History of solid organ transplant
- Under 18 years old
- Pregnant women
- History of cerebrovascular accident causing neurologic deficit
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Actively Recruiting
Research Team
K
Kimberly Hoang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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