Hematopoietic Somatic Mosaicism Is Associated With an Increased Risk of Postoperative Atrial Fibrillation.
Sandro Ninni, David Dombrowicz, Tanya Kuznetsova...
https://pubmed.ncbi.nlm.nih.gov/36990546Actively Recruiting
Age: 18Years +
All Genders
ID03376165
Longitudinal Study of Patients Undergoing Cardiac Surgery or Percutaneous Valve Implantation
Led by University Hospital, Lille · Updated on 2026-05-14
1500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients who undergo cardiac surgery or transcatheter valve implantation to understand predictors of major cardiovascular events after these procedures. The study focuses on how pre-operative leukocyte levels, fat, and heart muscle characteristics might be linked to outcomes after the intervention. This observational study is led by University Hospital, Lille and aims to track long-term heart health following surgery or valve implantation. Participants include patients scheduled for coronary artery bypass graft surgery, valvular surgery, or transcatheter valve implantation. There are no treatments assigned as this is an observational study. Researchers will monitor participants before and after their procedure to observe natural outcomes without altering care. During the study, participants will be followed for up to 10 years to track major cardiovascular events starting from the day of their intervention. Other outcomes monitored include myocardial injury within 3 days post-intervention, myocardial infarction and atrial fibrillation within 10 days, and major cardiovascular events within 1 year. The study collects detailed information to better understand risks and recovery after heart procedures.
CONDITIONS
Brief Title
Post-Operative Myocardial Incident & Atrial Fibrillation
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients scheduled for cardiac surgery, including coronary artery bypass graft surgery and/or valvular surgery
- Patients scheduled for transcatheter valve implantation
- Adults aged 18 years or older
You will not qualify if you...
- Pregnant women
- Patients requiring urgent surgery or intervention
- Patients unable to provide consent to the protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Up to 10 days following intervention
Participants undergo cardiac surgery or percutaneous valve implantation and initial assessments of heart function and injury.
Daily visits for up to 10 days
Long-term Monitoring
Duration - Up to 10 years
Participants are monitored for major cardiovascular events and atrial fibrillation after their cardiac intervention.
Periodic visits during follow-up (visit frequency varies)
Trial Site Locations
Total: 1 location
1
Hôpital Cardiologie, CHU
Lille, France
Actively Recruiting
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Research Team
D
David Montaigne, Prof.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Clonal Hematopoiesis Is Associated With Long-Term Adverse Outcomes Following Cardiac Surgery.
Sandro Ninni, Rocio Vicario, Augustin Coisne...
https://pubmed.ncbi.nlm.nih.gov/39206728