Surgery Followed by Radiation Therapy for Patients with Limited Spine Metastases Comparing Total Spine Removal or Partial Surgery with Different Radiation Approaches

What this Trial Is About

Researchers are evaluating treatment options for patients with limited spine metastases from solid cancers. This trial compares total spondylectomy followed by conventional radiotherapy with debulking surgery followed by either conventional radiotherapy or stereotactic body radiation therapy SBRT. The main goal is to assess local control of the cancer at one year after surgery. Participants will be randomly assigned to one of three groups total spondylectomy followed by conventional radiotherapy 20 Gy in 5 fractions, debulking surgery followed by conventional radiotherapy 20 Gy in 5 fractions, or debulking surgery followed by SBRT 24 Gy in 12 fractions. Total spondylectomy involves complete removal of the affected spine segment, while debulking surgery involves partial removal. Radiation treatments are delivered after surgery according to the assigned group. During the study, patients will undergo regular assessments including quality of life evaluations, pain control measurements, and monitoring for treatment-related side effects every three months up to one year after surgery. Researchers will also track overall survival and local control at 12 months. Participants will have preoperative MRI scans and follow-up visits to monitor progress and safety throughout the study period, which started in August 2022 and is expected to continue until July 2027.

Post Operative RT for Limited Spine Metastases