Postoperative Analgesia in Patients Undergoing Primary or Revision Knee Arthroplasty with Adductor Canal Block.
Alexander E Grant, Eric S Schwenk, Marc C Torjman...
https://pubmed.ncbi.nlm.nih.gov/28824869/Actively Recruiting
Led by University of Toronto · Updated on 2025-12-29
50
Participants Needed
1
Research Sites
4 weeks
Total Duration
Researchers are investigating pain management options for patients undergoing revision total knee arthroplasty rTKA, a common and often painful surgery. The study compares spinal anesthesia with intrathecal morphine IM to spinal anesthesia without IM, focusing on the risk of postoperative urinary retention POUR and pain control. This research is important because IM can reduce pain but may cause urinary retention, which increases infection risks, and there is limited evidence specifically for rTKA cases. Participants will be randomly assigned to one of two groups one receiving spinal anesthesia with IM plus single shot and continuous adductor canal blocks CACB and IPACK block, and the other receiving the same nerve blocks and spinal anesthesia but without IM. Both groups receive comprehensive nerve blocks and standard medications during surgery, with catheter placement for continuous nerve block infusion lasting 48-60 hours. The study is designed as a randomized, blinded trial to compare outcomes between these approaches. During the study, patients will be monitored closely for urinary retention and pain levels for 48 hours after spinal anesthesia. Assessments include pain at rest and movement, opioid use, and quality of recovery. Patients may be discharged with the nerve block catheter in place, with instructions for home care and follow-up phone assessments. The study aims to measure if avoiding IM can reduce urinary retention without worsening pain control, with all participants receiving detailed perioperative care and monitoring throughout the study period.
CONDITIONS
Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine
H
Hermann dos Santos Fernandes, MD, PhD
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University of Toronto
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) during pre-anesthesia consultation at the Pre-Admission Unit
Duration - Surgery day and up to 48-60 hours post-surgery
Participants undergo revision total knee arthroplasty surgery under spinal anesthesia with or without intrathecal morphine, combined with peripheral nerve blocks. Postoperative pain management includes continuous adductor canal block catheter infusion for 48-60 hours.
1 day of surgery with catheter placement and monitoring in the post anesthesia care unit and ward
Duration - Up to 48 hours after spinal anesthesia
Participants are followed for pain control, opioid consumption, quality of recovery, and monitoring for postoperative urinary retention for up to 48 hours after spinal anesthesia. Follow-up may be in-person if hospitalized or by phone if discharged early.
Up to 2 follow-up visits (in-person or phone assessments) within 48 hours post-surgery
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/29306574/University of Toronto
Lead Sponsor