Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID06974279

Precision Neuromodulation in Post-Stroke Aphasia Using TMS

Led by Medical College of Wisconsin · Updated on 2025-09-19

50

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia. This study aims to identify precise therapy targets using functional neuroimaging and inhibitory TMS and then compare the outcomes of excitatory TMS applied to these precision sites versus control sites. The main goal is to assess improvements in naming accuracy after treatment. Participants will be randomly assigned to one of two groups: one will receive SFA combined with excitatory TMS targeting a precision site, and the other will receive SFA combined with excitatory TMS targeting a control site. The TMS uses an intermittent theta burst stimulation protocol. SFA therapy is administered immediately after TMS in both groups. This design allows comparison of the benefit of precision-targeted TMS versus control TMS. During the study, researchers will measure changes in picture naming accuracy immediately after treatment and again 8 to 12 weeks later. Participants will undergo language and cognitive testing to evaluate progress. The study includes monitoring for safety and adherence, with detailed assessments to determine the therapy's impact on language abilities. The total duration includes treatment and follow-up periods to observe lasting effects.

CONDITIONS

Brief Title

Post-Stroke Aphasia TMS

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosed with left hemisphere stroke
  • Consent date on or after 1 month following stroke onset
  • Fluent in English
  • 18 years of age or older
Not Eligible

You will not qualify if you...

  • Severe cognitive, auditory, or visual impairments that interfere with testing
  • Major untreated or unstable psychiatric diseases such as schizophrenia or bipolar disorder
  • Untreated or unstable chronic medical conditions
  • Presence of cardiac stimulators, pacemakers, neurostimulators, medication infusion devices, scalp or eye implants, or metal fragments in the body
  • Pregnancy
  • History of skull fractures or skin diseases
  • History of ongoing or unmanaged seizures
  • Factors lowering seizure thresholds such as pro-convulsant medications, untreated sleep deprivation, alcoholism, or illegal drug abuse
  • History of dyslexia or other developmental learning disabilities

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Implementation

Duration - Not specified

Participants receive excitatory TMS targeting either a precision site or a control site, immediately followed by speech fluency activation (SFA) therapy.

Follow-up

Duration - Approximately 8 to 12 weeks after treatment

Participants are assessed for changes in picture naming accuracy immediately after and 8 to 12 weeks after the last SFA+TMS treatment.

Trial Site Locations

Total: 1 location

1

Medical College of Wisconsin

Milwaukee, Wisconsin, United States, 53226

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Research Team

S

Sidney Schoenrock, MA

A

Ari Hjelmeseth

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Published Research Related To This Trial

Interhemispheric Plasticity following Intermittent Theta Burst Stimulation in Chronic Poststroke Aphasia.

Joseph C Griffis, Rodolphe Nenert, Jane B Allendorfer...

https://pubmed.ncbi.nlm.nih.gov/26881111

Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996.

E M Wassermann

https://pubmed.ncbi.nlm.nih.gov/9474057

Seizures from transcranial magnetic stimulation 2012-2016: Results of a survey of active laboratories and clinics.

Adam J Lerner, Eric M Wassermann, Diana I Tamir

https://pubmed.ncbi.nlm.nih.gov/31104898

Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.

Simone Rossi, Andrea Antal, Sven Bestmann...

https://pubmed.ncbi.nlm.nih.gov/33243615

Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research.

Simone Rossi, Mark Hallett, Paolo M Rossini...

https://pubmed.ncbi.nlm.nih.gov/19833552