Actively Recruiting
Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological Malignancies
Led by Hospital Israelita Albert Einstein · Updated on 2019-02-01
50
Participants Needed
1
Research Sites
416 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate the clinical efficacy of cyclophosphamide in patients receiving a bone marrow graft from a matched unrelated donor in overall survival, progression free survival and cumulative incidence of acute and chronic GvHD. Thirty patients will receive cyclophosphamide while twenty patients will receive antihuman T-lymphocyte immune globulin (ATG).
CONDITIONS
Official Title
Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women of any age
- Indication for hematopoietic stem cell transplant (HSCT) without a matched sibling donor
- Availability of a matched unrelated donor (HLA 10 x 10 or 9 x 10)
- Diagnosis of hematological malignancy
You will not qualify if you...
- Acute leukemias not in complete response (more than 5% blasts in bone marrow)
- Chemorefractory lymphoproliferative disease
- Active uncontrolled infection
- Hematopoietic cell transplantation-comorbidity index (HCT-CI) greater than 3
- Severe organ dysfunction including heart ejection fraction less than 45%, glomerular filtration rate less than 50 mL/hour, or pulmonary DLCO less than 50%
- Prior allogeneic bone marrow transplantation
- Contraindication to cyclophosphamide or ATG
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospita Israelita Albert Eintein
São Paulo, São Paulo, Brazil, 05652-900
Actively Recruiting
Research Team
A
Andreza A Feitosa Ribeiro
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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