Actively Recruiting
POST URS Chemotherapy Instillation
Led by Carmel Medical Center · Updated on 2023-12-20
264
Participants Needed
10
Research Sites
249 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to evaluate the safety and oncological outcomes of single chemotherapy bladder instillation following endoscopic treatment for UTUC in UTUC suspected patients .The main aim is to determine the efficacy of a single, post URS, chemotherapy bladder instillation to reduce IVR. Participants will be given single chemotherapy bladder instillation within 24h following ureteroscopy and will follow routine follow-up for IVR which will include white light cystoscopy ;patients with suspected IVR (based on either imaging or cystoscopy) will undergo TURBT.
CONDITIONS
Official Title
POST URS Chemotherapy Instillation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Radiographic and/or cytological suspicion for UTUC
- Planned endoscopic procedure for treatment or diagnosis of UTUC
- Patients with bladder cancer history are eligible if they have had no recurrence within the last two years and are not on active bladder irrigation protocol
- Patients with history of UTUC are eligible if their last endoscopic treatment or radical nephroureterectomy was more than one year prior to enrollment
- Age 18 years or older
- Performance status ECOG 0-2
You will not qualify if you...
- Previous bladder or prostate radiotherapy
- Bladder cancer history with active bladder irrigation protocols or active disease within two years prior to enrollment
- Previously treated UTUC within one year prior to enrollment
- Presence of metastatic disease
AI-Screening
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Trial Site Locations
Total: 10 locations
1
Assuta Ashdod Hospital
Ashdod, Israel
Actively Recruiting
2
Soroka University Medical Center
Beersheba, Israel
Actively Recruiting
3
Shamir Medical Center
Be’er Ya‘aqov, Israel
Actively Recruiting
4
Bnai Zion Medical Center
Haifa, Israel, 31048
Actively Recruiting
5
Carmel Medical Center
Haifa, Israel, 34362
Actively Recruiting
6
Rambam Health Care Campus
Haifa, Israel
Actively Recruiting
7
Rabin Medical Center - Beilinson and Hasharon
Petah Tikva, Israel, 4937211
Actively Recruiting
8
Kaplan Medical Center
Rehovot, Israel
Actively Recruiting
9
Ziv Medical Center
Safed, Israel
Actively Recruiting
10
Tel Aviv Sourasky Medical Center - Ichilov
Tel Aviv, Israel
Actively Recruiting
Research Team
Y
Yuval Freifeld, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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