Studying Immune Responses After Vaccination in Adults Through Biological Sample Collection

What this Trial Is About

Vaccination plays a crucial role in reducing illness and death from infectious diseases worldwide. Researchers are studying how the immune system responds to various vaccines, including influenza, pneumococcal, MMR, and yellow fever vaccines, especially in different groups such as healthy individuals, people living with HIV, COPD patients, and those with primary immune deficiencies. This observational study aims to better understand the immune responses triggered by these vaccines using modern immune analysis techniques. The study collects blood samples from participants receiving vaccines as part of their routine care. It uses advanced methods like transcriptional analysis to examine the innate immune response 24 hours after vaccination, as well as measuring B and T cell responses and specific antibody production at various times up to one month post-vaccination. The goal is to identify immunological markers that relate to vaccine protection in diverse populations. Participants will provide samples before vaccination and at several points afterward, including days 7, 14, and one month. Researchers will perform detailed laboratory tests to analyze immune cells and antibodies. The study carefully observes changes in immune responses over time to improve knowledge about how vaccines work in different people. The total participation time varies depending on vaccination schedules, with ongoing monitoring of immune markers to support vaccine research.

Post-Vaccination Biological Collection