Actively Recruiting
Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Led by Rush University Medical Center · Updated on 2025-10-20
250
Participants Needed
5
Research Sites
177 weeks
Total Duration
On this page
Sponsors
R
Rush University Medical Center
Lead Sponsor
H
Hospital Civil de Guadalajara
Collaborating Sponsor
AI-Summary
What this Trial Is About
Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.
CONDITIONS
Official Title
Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Receiving invasive mechanical ventilation for 24 hours or more
- Body mass index (BMI) of 40 kg/m2 or higher
- Undergoing planned removal of the breathing tube (extubation) as decided by your treatment team
- Arterial pH of 7.35 or higher, or venous pH of 7.31 or higher within 30 minutes of spontaneous breathing trial
You will not qualify if you...
- Pregnant
- Use of extracorporeal membrane oxygenation (ECMO)
- Presence of a chronic tracheostomy
- Unplanned or accidental removal of the breathing tube
- Terminal or compassionate extubation
- Contraindications to using noninvasive ventilation (NIV)
- Intubation due to acute exacerbation of chronic obstructive pulmonary disease (COPD)
- Underlying neuromuscular disease
- Patient or family requested no reintubation
- History of chronic hypercapnic respiratory failure requiring home NIV
- Currently enrolled in another outcome study
- Treating clinician considers HFNC or NIV mandatory or contraindicated for the patient
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Rush University Medical Center
Chicago, Illinois, United States, 60612
Actively Recruiting
2
Central DuPage Hospital
Winfield, Illinois, United States, 60190
Not Yet Recruiting
3
McGovern Medical School, The University of Texas Health Science Center
Houston, Texas, United States, 77030
Actively Recruiting
4
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
5
Hospital Civil Fray Antonio Alcalde
Guadalajara, Jalisco, Mexico, 44280
Actively Recruiting
Research Team
R
Ramandeep Kaur, PhD
CONTACT
B
Babak Mokhlesi, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here