Actively Recruiting
Postoperation Maintenance Therapy for Resectable Liver Metastases of Colorectal Cancer Guided by ctDNA
Led by Sixth Affiliated Hospital, Sun Yat-sen University · Updated on 2023-04-04
346
Participants Needed
1
Research Sites
417 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare in resectable liver metastases colorectal cancer patients.The main question it aims to answer is to investigate whether the progression-free survival (PFS) of resectable colorectal liver metastasis (CRLM) patients with positive ctDNA after surgery is superior with the combination of adjuvant chemotherapy and maintenance therapy compared to adjuvant chemotherapy alone.
CONDITIONS
Official Title
Postoperation Maintenance Therapy for Resectable Liver Metastases of Colorectal Cancer Guided by ctDNA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Both males and females, aged 18-75 years
- Patients with liver metastatic colorectal cancer who have undergone R0 resection based on MDT evaluation, including those treated with ablation achieving similar R0 effect
- Postoperative ctDNA-positive patients
- ASA grade less than IV and/or ECOG performance status score 2 or less
- Participants must understand the study and voluntarily sign informed consent
You will not qualify if you...
- Patients with distant metastases to other sites such as pelvis, ovaries, or peritoneum
- History of other malignant tumors
- Severe liver, kidney, cardiorespiratory, or coagulation dysfunction or other diseases that prevent chemotherapy tolerance
- Allergy to any study components
- Prior investigational drug treatment for tumors
- Severe uncontrolled infections or other severe uncontrolled diseases
- Factors affecting study results or leading to early termination like alcoholism, drug abuse, serious diseases, or severe lab abnormalities
- History of severe mental illness
- Pregnant or lactating women
- Other clinical or laboratory conditions deemed unsuitable by researchers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The Sixth Affiliate Hospital of Sun Yat-Sen University
Guangzhou, Guangdong, China
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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