Actively Recruiting
Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery
Led by Uppsala University · Updated on 2026-05-12
2000
Participants Needed
13
Research Sites
148 weeks
Total Duration
On this page
Sponsors
U
Uppsala University
Lead Sponsor
U
Uppsala University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery. Urinary biomarkers are intended to be evaluated as predictors of PO-AKI in the same subjects. The study employs modern standardized classifications for AKI to comprehensively address the issue of PO-AKI in children. Describing the incidence and identifying risk factors for PO-AKI will play a crucial role in developing preventive strategies aimed at reducing associated mortality and morbidity. Furthermore, investigating the relationship between urinary biomarkers of renal injury and PO-AKI will provide valuable insights into assessing postoperative renal function in paediatric patients, especially when repeated blood sampling is not feasible.
CONDITIONS
Official Title
Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Elective, urgent or emergency in-patient major non-cardiac surgical procedures performed under general anaesthesia with or without regional analgesia with a planned procedure duration of at least 60 minutes.
- Paediatric patients (0-16 years old)
You will not qualify if you...
- Declined participation.
- Ongoing renal replacement therapy
- Acute Kidney Injury (according to KDIGO)
- Known chronic kidney disease
- Procedure involving surgery of the kidney
- Procedures requiring clamping of blood flow to or from the kidney
- Body weight <2kg
- Procedure involving contrast administration
- Established rhabdomyolysis (CK-levels >1500 U/L)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 13 locations
1
Perth Children's Hospital
Perth, Western Australia, Australia, 6909
Not Yet Recruiting
2
The Kids Research Institute Australia
Perth, Western Australia, Australia, 6909
Not Yet Recruiting
3
Hospital das Clínicas HCFMUSP
São Paulo, Brazil
Not Yet Recruiting
4
Hospices Civils de Lyon
Lyon, France
Not Yet Recruiting
5
IRCCS Istituto Giannina Gaslini
Genova, Italy
Not Yet Recruiting
6
University Hospital of Belgrade
Belgrade, Serbia
Not Yet Recruiting
7
Sahlgrenska University Hospital
Gothenburg, Sweden
Not Yet Recruiting
8
Skåne University Hospital
Lund, Sweden
Not Yet Recruiting
9
Karolinska University Hospital
Stockholm, Sweden
Actively Recruiting
10
Uppsala University Hospital
Uppsala, Sweden
Actively Recruiting
11
University Hospital Basel
Basel, Switzerland
Not Yet Recruiting
12
University Hospital Bern
Bern, Switzerland
Not Yet Recruiting
13
University Hospital Geneva
Geneva, Switzerland
Not Yet Recruiting
Research Team
R
Robert Frithiof, Md, PhD
CONTACT
A
Arash Emami, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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